Results 171 to 180 of about 49,984 (235)

Biomimetic MCC950‐loaded cerium‐layered double hydroxide nanoparticles for targeted treatment of Type 1 diabetes in streptozotocin‐induced mice

open access: yesBritish Journal of Pharmacology, Volume 183, Issue 16, Page 4919-4938, August 2026.
The CLMBM nanoparticle (NP) system demonstrates strong and targeted anti‐ROS, antiapoptotic and anti‐inflammatory properties within the pancreas, thereby inhibiting the onset and progression of type 1 diabetes. Background and Purpose The destruction of β‐cells in type 1 diabetes is driven by signalling cascades that ultimately lead to cell apoptosis ...
Huiwen Pang   +9 more
wiley   +1 more source

Evaluating the effect of crocin on contrast-induced nephropathy in rats. [PDF]

open access: yesAvicenna J Phytomed
Zolfaghari Farajerdi M   +6 more
europepmc   +1 more source

Fn14 signalling participates in pristane‐induced murine lupus through exacerbating oxidative stress

open access: yesBritish Journal of Pharmacology, Volume 183, Issue 16, Page 5102-5119, August 2026.
Background and Purpose Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by oxidative stress and immune dysregulation. Fibroblast growth factor‐inducible 14 (Fn14) has been implicated in tissue injury, but its specific role in SLE pathogenesis remains unclear.
Zhu Yan   +8 more
wiley   +1 more source

TREM2 in Macrophages Promotes Renal Fibrosis via Activation of β‐Catenin Signalling Pathway in Obstructive Nephropathy

open access: yesCell Proliferation, Volume 59, Issue 8, August 2026.
Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) promotes obstructive nephropathy progression by activating the β‐catenin signalling pathway, driving M2 macrophage polarisation, migration and fibrogenic gene expression. targeted inhibition of TREM2 thus represents a promising novel strategy against renal fibrosis.
Jia Wei   +7 more
wiley   +1 more source

Lysine l‐Lactylation: Bridging Metabolism, Chromatin and Disease

open access: yesCell Proliferation, Volume 59, Issue 8, August 2026.
Enzymatic regulation of KL‐la. The enzymatic regulation of KL‐la involves two distinct pathways for L‐lactate accumulation: intracellular production through glycolysis‐derived pyruvate conversion by lactate dehydrogenase (LDH) or direct cellular uptake via monocarboxylate transporters (MCTs). These L‐lactate pools fuel two distinct lactylation pathways—
Anoosha Malik   +10 more
wiley   +1 more source

Nicorandil for prevention of contrast-induced nephropathy in patients undergoing coronary angiography: a meta-analysis. [PDF]

open access: yesFuture Cardiol
Shaukat A   +16 more
europepmc   +1 more source

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