Results 191 to 200 of about 448,489 (363)

Eplerenone improves kidney function and cardiac performance in obese male mice

open access: yesDiabetic Medicine, EarlyView.
Abstract Aims Renin‐angiotensin‐aldosterone system (RAAS) activation mediates obesity‐associated cardiorenal dysfunction. Due to an incomplete understanding of the molecular mechanisms, the clinical use of RAAS antagonism in obesity‐associated cardiometabolic complications remains uncertain.
Ayman K. Banah   +8 more
wiley   +1 more source

Pathophysiology of type 2 diabetes: A focus on the metabolic differences among southeast Asian, Chinese and Indian populations and how this impacts treatment

open access: yesDiabetes, Obesity and Metabolism, EarlyView.
Abstract The prevalence of type 2 diabetes has been rising in China, India and Southeast Asia for decades, challenging their healthcare systems. With region‐specific determinants such as genetics, lifestyle transition and early‐life environment, people with type 2 diabetes showed their unique phenotypes, including being, on average, younger in age ...
Yuzi Cao   +3 more
wiley   +1 more source

Modifying the Risk of Contrast‐Associated Acute Kidney Injury in Percutaneous Coronary Interventions and Transcatheter Aortic Valve Implantations

open access: yesJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Briggs S. Carhart   +2 more
doaj   +1 more source

An interpretable machine learning model for predicting metabolic dysfunction‐associated steatotic liver disease in patients with type 2 diabetes

open access: yesDiabetes, Obesity and Metabolism, EarlyView.
Abstract Aim Patients with type 2 diabetes mellitus (T2DM) exhibit an elevated prevalence of metabolic dysfunction‐associated steatotic liver disease (MASLD) and are at greater risk of liver‐related adverse events. Existing non‐invasive tools show limited diagnostic performance in this population.
Zhuolin Zhou   +5 more
wiley   +1 more source

Non‐linear relationship between liver fibrosis and femoral neck bone mineral density in metabolic dysfunction‐associated fatty liver disease patients with type 2 diabetes mellitus

open access: yesJournal of Diabetes Investigation, EarlyView.
Our study investigates the relationship between hepatic fibrosis and femoral neck bone mineral density (BMD) in MAFLD patients with type 2 diabetes mellitus (T2DM‐MAFLD) and assesses the potential influence of metabolic factors. We found a non‐linear relationship between hepatic fibrosis and femoral neck BMD, particularly evident in postmenopausal ...
Jie Tao   +3 more
wiley   +1 more source

NSUN2‐mediated m5C methylation modification regulates trophoblast cell proliferation, apoptosis, and autophagy in gestational diabetes mellitus

open access: yesJournal of Diabetes Investigation, EarlyView.
ABSTRACT Introduction Gestational diabetes mellitus (GDM) represents one of the most prevalent medical complications during pregnancy. Emerging evidence has implicated NOL1/NOP2/SUN domain (NSUN)2‐mediated 5‐methylcytosine (m5C) methylation modifications in various pathological conditions. This study aimed to investigate the role of m5C modification in
Jiujiu Liu   +3 more
wiley   +1 more source

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