Results 51 to 60 of about 899,795 (311)

A versatile genetic-encoded reporter for magnetic resonance imaging

Heliyon, 2023
It has been a long-cherished wish in biomedicine research to have an imaging tool to visualize gene expression, with good spatiotemporal resolution, in rodent and primate animals noninvasively and longitudinally.
Haiyang Yang, Zhengjiang Qian, Chunhua Liu, Changjun Tie, Aoling Cai, Jie Wang, Yao Xing, Jun Xia, Xiang Li   +8 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Development of nanostars as a biocompatible tumor contrast agent: toward in vivo SERS imaging

, 2016
Antoine D’Hollander,1–3 Evelien Mathieu,1,4 Hilde Jans,1 Greetje Vande Velde,2,3 Tim Stakenborg,1 Pol Van Dorpe,1,4 Uwe Himmelreich,2,3 Liesbet Lagae1,4 1Department of Life Science Technology, Imec, 2Department of Imaging and Pathology ...
Vande Velde, Greetje, D'Hollander, Antoine, Stakenborg, Tim, Himmelreich, Uwe, Vande Velde G, Mathieu, E., Van Dorpe P, Jans, Hilde, Van Dorpe, Pol, Lagae, Liesbet, Stakenborg T, D’Hollander A, Jans H, Himmelreich U, Lagae L, Mathieu E   +15 more
core   +1 more source

Tumour cell labelling by magnetic nanoparticles with determination of intracellular iron content and spatial distribution of the intracellular iron [PDF]

, 2013
Magnetically labelled cells are used for in vivo cell tracking by MRI, used for the clinical translation of cell-base therapies. Studies involving magnetic labelled cells may include separation of labelled cells, targeted delivery and controlled release ...
Wang, Zhigang, Cuschieri, Alfred, Zhigang Wang, Alfred Cuschieri   +3 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Stable and inert manganese complexes for magnetic resonance imaging

Comptes Rendus. Chimie
Paramagnetic Mn$^{2+}$ complexes are intensively investigated as alternatives to replace the currently used, Gd-based clinical contrast agents in Magnetic Resonance Imaging (MRI).
Ndiaye, Daouda, Tóth, Éva
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Polypyrrole-Coated Perfluorocarbon Nanoemulsions as a Sono-Photoacoustic Contrast Agent

, 2017
A new contrast agent for combined photoacoustic and ultrasound imaging is presented. It has a liquid perfluorocarbon (PFC) core of about 250 nm diameter coated by a 30 nm thin polypyrrole (PPy) doped polymer shell emulsion that represents a broadband ...
Martin Frenz, Lilo D. Pozzo, Yoon, Soon Joon, Frenz, Martin, Pozzo, Lilo D., Matthew O’Donnell, O’Donnell, Matthew, Ivan Pelivanov, Li, David S., David S. Li, Pelivanov, Ivan, Soon Joon Yoon   +11 more
core   +1 more source

Biocompatible Nanocomplexes for Molecular Targeted MRI Contrast Agent

Nanoscale Research Letters, 2009
Accurate diagnosis in early stage is vital for the treatment of Hepatocellular carcinoma. The aim of this study was to investigate the potential of poly lactic acid–polyethylene glycol/gadolinium–diethylenetriamine-pentaacetic acid (PLA–
Yu Dexin, Ma Chunhong, Wang Shaojie, Lu Zaijun, Chen Zhijin, Zhang Na   +5 more
doaj   +1 more source