Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Enhancing Conjunctival Vasculature Imaging: A Multi-Objective Cuckoo Search Approach for Contrast Enhancement Optimization. [PDF]
Llorens-Quintana C +3 more
europepmc +1 more source
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Improved leukocyte classification in bone marrow cytology using convolutional neural network with contrast enhancement. [PDF]
Mehmood S +6 more
europepmc +1 more source
Comparing the Efficacy of a Combination of Diffusion-Weighted Imaging and T2-STIR (Short Tau Inversion Recovery) Imaging With Contrast-Enhanced MRI in the Evaluation of Perianal Fistula [PDF]
Pooja Aggarwal +3 more
openalex +1 more source
Incidence of Contrast-Induced Nephropathy after Contrast-Enhanced Computed Tomography in the Outpatient Setting [PDF]
Alice M. Mitchell +3 more
openalex +1 more source
Strength through diversity: how cancers thrive when clones cooperate
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
In-pixel foreground and contrast enhancement circuits with customizable mapping. [PDF]
Udoy MRI, Islam MM, Johnson E, Aziz A.
europepmc +1 more source
Contrast Enhancement Based on Histogram Stretch and Clustering of Brightness in Invisible Scene
Hiroshi Kawarabuki, Kazunori Onoguchi
openalex +2 more sources

