Results 111 to 120 of about 1,499,696 (300)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
The effects of declarative learning on early and late motor skill learning
npj Science of LearningMotor skill learning and performance is driven by the interplay between declarative and nondeclarative systems, which can complement or interfere with one another depending on task demands.
Mohan W. Gupta, Timothy C. Rickard
doaj +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Influence diagnostics on the coefficient of variation of elliptically contoured distributions
, 2011 In this article, we study the behavior of the coefficient of variation (CV) of a random variable that follows a symmetric distribution in the real line. Specifically, we estimate this coefficient using the maximumlikelihood (ML) method.
Galea, Manuel +3 more
core
Emotions and background music: an educative resource [PDF]
, 2017 Escuchar música parece tener un efecto en las emociones que experimenta el alumnado. Sin embargo, esta relación parece estar mediada por factores sociales, culturales y cognitivos.
Franco Caballero, Pablo D. +2 more
core
Impact of Life History on Fear Memory and Extinction
Frontiers in Behavioral Neuroscience, 2016 Behavioral profiles are strongly shaped by an individual’s whole life experience. The accumulation of negative experiences over lifetime is thought to promote anxiety-like behavior in adulthood (‘allostatic load hypothesis’).
Jasmin Remmes +12 more
doaj +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
L’utilisation du morphème BE en anglais langue faible [PDF]
, 2012 Cet article examine la construction d’un aspect du système temporel chez un enfant bilingue pendant une période de développement rapide d’une de ses langues, l’anglais.
Jisa, Harriet
core +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source