Results 141 to 150 of about 82,677 (285)

Deep learning‐enhanced 3D imaging unveils semaglutide impact on cardiac fibrosis

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and Purpose Myocardial fibrosis (MF), a hallmark of structural cardiac remodelling, drives disease progression across most forms of heart failure and plays a central role in heart failure with preserved ejection fraction (HFpEF). Despite its clinical relevance, effective treatments remain scarce.
Sheyla Barrado‐Ballestero   +11 more
wiley   +1 more source

Targeting ROCK1/YAP1 Axis Ameliorates Inflammation‐Induced Prostatic Hyperplasia via Stabilising SIRT1‐Dependent Mitochondrial Dynamics

open access: yesCell Proliferation, EarlyView.
Prostate‐specific YAP1 overexpression induces pathological BPH phenogenesis. Targeting ROCK1/YAP1 with fasudil and verteporfin alleviates inflammatory BPH lesions. YAP1 orchestrates mitochondrial dysfunction and oxidative stress via suppressing SIRT1 function.
Dongxu Lin   +9 more
wiley   +1 more source

Contrast induced nephropathy in cardiac interventions

open access: yesIndian Heart Journal, 2014
Vicar Jan   +4 more
doaj   +1 more source

Eplerenone improves kidney function and cardiac performance in obese male mice

open access: yesDiabetic Medicine, EarlyView.
Abstract Aims Renin‐angiotensin‐aldosterone system (RAAS) activation mediates obesity‐associated cardiorenal dysfunction. Due to an incomplete understanding of the molecular mechanisms, the clinical use of RAAS antagonism in obesity‐associated cardiometabolic complications remains uncertain.
Ayman K. Banah   +8 more
wiley   +1 more source

Modifying the Risk of Contrast‐Associated Acute Kidney Injury in Percutaneous Coronary Interventions and Transcatheter Aortic Valve Implantations

open access: yesJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Briggs S. Carhart   +2 more
doaj   +1 more source

Pathophysiology of type 2 diabetes: A focus on the metabolic differences among southeast Asian, Chinese and Indian populations and how this impacts treatment

open access: yesDiabetes, Obesity and Metabolism, EarlyView.
Abstract The prevalence of type 2 diabetes has been rising in China, India and Southeast Asia for decades, challenging their healthcare systems. With region‐specific determinants such as genetics, lifestyle transition and early‐life environment, people with type 2 diabetes showed their unique phenotypes, including being, on average, younger in age ...
Yuzi Cao   +3 more
wiley   +1 more source

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