Results 61 to 70 of about 515,616 (281)

Prevention of contrast‐induced nephropathy by adequate hydration combined with isosorbide dinitrate for patients with renal insufficiency and congestive heart failure

Clinical Cardiology, 2019
Adequate hydration remains the mainstay of contrast‐induced nephropathy prevention, and nitrates could reduce cardiac preload.
G. Qian, Changfu Liu, Jun Guo, W. Dong, J. Wang, Yun-Dai Chen   +5 more
semanticscholar   +1 more source

Multi‐Omic Profiling Reveals Immune Cell Priming Signature Linked to Lupus Prognosis

Arthritis &Rheumatology, EarlyView.
Objective Systemic lupus erythematosus (SLE) is a multiorgan disease with widespread immune dysregulation and significant unmet clinical need. Blood‐based gene expression studies have advanced our understanding of SLE pathogenesis but may overlook critical tissue‐specific mechanisms that drive disease heterogeneity and progression.
Michael A. Smith, Dominic Sinibaldi, Saifur Rahman, Chia‐Chien Chiang, Anna M. Hansen, Jill Henault, Carlos P. Roca, Shu Wang, Kamelia Zerrouki, Rebecca Filippi, Christopher Groves, Zerai Manna, Jun Chu, Michael Davis, Sarthak Gupta, Christopher Morehouse, Melissa de los Reyes, Rachel Ettinger, Roland Kolbeck, Mariana J. Kaplan, Miguel A. Sanjuan, Richard M. Siegel, Sarfaraz A. Hasni, Kerry A. Casey   +23 more
wiley   +1 more source

Quercetin, a Promising Clinical Candidate for The Prevention of Contrast-Induced Nephropathy

International Journal of Molecular Sciences, 2019
Iodinated contrast media (CM) are the leading cause of acute renal failure of toxic origin. Between 21% and 50% of patients that receive them develop contrast-induced nephropathy (CIN).
Laura Vicente-Vicente, D. González-Calle, Alfredo G. Casanova, M. Hernández-Sánchez, M. Prieto, J. C. Rama-Merchán, J. Martín‐Moreiras, F. Martín-Herrero, P. Sánchez, F. López-Hernández, I. Cruz-González, A. Morales   +11 more
semanticscholar   +1 more source

IgG Glycosylation‐Dependent CLEC7A Signaling Drives Podocyte Dysfunction in Lupus Nephritis

Arthritis &Rheumatology, EarlyView.
Objective Lupus nephritis (LN) is a severe complication of systemic lupus erythematosus (SLE) that can lead to end‐stage kidney disease and increased mortality. IgG from patients with LN displays abnormal glycosylation, contributing to podocyte injury.
Rohit Upadhyay, Alexia Orellana, George C. Tsokos, Rhea Bhargava   +3 more
wiley   +1 more source

Assessing contrast-induced nephropathy risk in older adults undergoing coronary angiography and intervention: The CV/GFR ratio versus Mehran score

SAGE Open Medicine
Background: Contrast-induced nephropathy is a prevalent cause of hospital-acquired renal insufficiency and increases adverse events in older patients undergoing angiography and percutaneous coronary intervention.
Tan Van Nguyen, Nhi Tuyet Quang, Weber Liu, Ngo Thi Kim Trinh, Tu Ngoc Nguyen   +4 more
doaj   +1 more source

Contrast‐induced nephropathy after cardiac resynchronization therapy implant impairs the recovery of ejection fraction in responders

ESC Heart Failure, 2019
Data regarding contrast‐induced nephropathy (CIN) after cardiac resynchronization therapy (CRT) implant are limited. We aimed to investigate the incidence and determinants of CIN and its impact on CRT response and outcomes.
T. Strisciuglio, G. Ammirati, V. Pergola, L. Imparato, C. Carella, Elisabeta Koci, R. Chiappetti, F. G. Abbate, V. L. La Fazia, A. Viggiano, B. Trimarco, A. Rapacciuolo   +11 more
semanticscholar   +1 more source

Evaluating and leveraging large language models in clinical pharmacology and therapeutics assessment: From exam takers to exam shapers

British Journal of Clinical Pharmacology, EarlyView.
Aims In medical education, the ability of large language models (LLMs) to match human performance raises questions about their potential as educational tools. This study evaluates LLMs' performance on Clinical Pharmacology and Therapeutics (CPT) exams, comparing their results to medical students and exploring their ability to identify poorly formulated
Alexandre O. Gérard, Diane Merino, Marc Labriffe, Fanny Rocher, Delphine Viard, Laurence Zemori, Thibaud Lavrut, Erik M. Donker, Joost D. Piët, Jean‐Paul Fournier, Milou‐Daniel Drici, Alexandre Destere   +11 more
wiley   +1 more source

Contrast-induced nephropathy after computed tomography

Brazilian Journal of Nephrology, 2015
Introduction: Contrast induced nephropathy is the third most prevalent preventable cause of acute kidney injury in hospitalized patients. It defined as an absolute increase in serum creatinine ≥ 0.5 mg/dL and relative ≥ 25% increase.
Luciano da Silva Selistre, Vandréa Carla de Souza, Laurence Dubourg, Mário Bernardes Wagner, João Rubião Hoefel Filho, David Saitovitch   +5 more
doaj   +1 more source

A novel rat model of contrast-induced nephropathy based on dehydration.

Journal of Pharmacological Sciences, 2019
BACKGROUND Contrast-induced nephropathy (CIN) is a frequent cause of hospital-acquired acute kidney injury. Previous animal models developed to explore the pathogenesis of CIN were based primarily on surgery or indomethacin treatment.
Kun Liu, Ling-yun Zhou, Dai-yang Li, Wen-jing Cheng, Wen-jun Yin, Can Hu, Yue-Liang Xie, Jiang-lin Wang, Shan-ru Zuo, Lin-hua Chen, Ge Zhou, Xiao-cong Zuo   +11 more
semanticscholar   +1 more source

Blood pressure effects of SGLT2 inhibitors and GLP‐1 receptor agonists: Mechanisms, trial evidence and Real‐world data

British Journal of Clinical Pharmacology, EarlyView.
SGLT2 inhibitors and GLP‐1 receptor agonists modestly lower blood pressure across diverse patient populations, including those without diabetes. These effects appear largely independent of glycaemic control and offer additive value in high‐risk patients with overlapping comorbidities.
Andrej Belančić, Yusuf Ziya Sener, Marijana Vučković, Joseph Edgar Blais, Almir Fajkić, Emina Sher, Mislav Radić, Josipa Radić   +7 more
wiley   +1 more source