Results 71 to 80 of about 7,026,740 (341)
FEBS Letters, EarlyView.At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom +3 more
wiley +1 more source
Huli yanjiu, 2022 This paper summarized clinical manifestations，occurrence time，risk factors and management of delayed hypersensitivity reactions to iodinated contrast media in contrast⁃enhanced CT，in order to increase attention of medical，technical and nursing parties on
GUO Can, CAO Ying, ZENG Xiaohong
doaj
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Patients at risk for contrast-induced acute kidney injury
Italian Journal of Medicine, 2013 Subjects with hypovolemia and/or dehydration and pre-existing renal failure are considered at highest risk for radiocontrast-medium-induced acute kidney injury (RCI-AKI), and this risk increases in the presence of glomerular filtration rate or creatinine
Michele Meschi +6 more
doaj +1 more source
Comparative Effect of Contrast Media Type on the Incidence of Contrast-Induced Nephropathy
Annals of Internal Medicine, 2016 Iodine contrast media are essential to many diagnostic and therapeutic procedures that involve imaging. An important potential side effect is contrast-induced nephropathy (CIN), most commonly defined in past studies as an increase in serum creatinine ...
J. Eng +10 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
Contrast Media Induced Kounis Syndrome: A Case Report
Diagnostics, 2019 Kounis syndrome is a rare anaphylactic reaction leading to coronary spasm, acute plaque rupture, or intrastent stenosis. Many types of medicine or environmental factors can potentially trigger Kounis syndrome by mast cell allergic reactions.
Da-Sen Chien +4 more
doaj +1 more source
Management of hypersensitivity reactions to contrast media
Allergy, Asthma & Respiratory Disease, 2023 Jang-Ho Seo +4 more
semanticscholar +1 more source
NLRP3 inflammasome mediates contrast media-induced acute kidney injury by regulating cell apoptosis
Scientific Reports, 2016 Iodinated contrast media serves as a direct causative factor of acute kidney injury (AKI) and is involved in the progression of cellular dysfunction and apoptosis.
Jianxiao Shen +12 more
semanticscholar +1 more source