Results 101 to 110 of about 26,557 (311)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

A CONTRASTIVE STUDY OF RELATIVIZATION IN ENGLISH AND ARABIC WITH REFERENCE TO TRANSLATION PEDAGOGY [PDF]

, 2012
This thesis presents a theoretical overview of relativization in English, relativization in Arabic, and contrasts between them. It also investigates the problems encountered by fourth-year English department students of El-Mergib University in Libya in ...
ZAGOOD, MOHAMMED,JUMA,M., Zagood, Mohammed Juma M   +1 more
core  

MetAug: Contrastive Learning via Meta Feature Augmentation [PDF]

, 2022
What matters for contrastive learning? We argue that contrastive learning heavily relies on informative features, or "hard" (positive or negative) features.
Qiang, Wenwen, Su, Bing, Li, Jiangmeng, Xiong, Hui, Zheng, Changwen   +4 more
core  

Hodge-Aware Contrastive Learning

ICASSP 2024 - 2024 IEEE International Conference on Acoustics, Speech and Signal Processing (ICASSP)
4 pages, 2 ...
Möllers, A., Immer, A., Fortuin, V., Isufi, E.   +3 more
openaire   +3 more sources

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Course Recommendation Model Based on Layer Dropout Graph Differential Contrastive Learning

IEEE Access
At present, the course recommendation model of graph collaborative filtering mainly uses bipartite graph modeling to obtain user-course cooperative relationship.
Yong Ouyang, Hao Long, Rong Gao, Jinghang Liu   +3 more
doaj   +1 more source

Decoupled Contrastive Learning for Federated Learning

CoRR
Federated learning is a distributed machine learning paradigm that allows multiple participants to train a shared model by exchanging model updates instead of their raw data. However, its performance is degraded compared to centralized approaches due to data heterogeneity across clients. While contrastive learning has emerged as a promising approach to
Hyungbin Kim, Incheol Baek, Yon Dohn Chung   +2 more
openaire   +2 more sources

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source