Results 11 to 20 of about 2,919 (202)

Advancing precision oncology through systematic germline and tumor genetic analysis: The oncogenetic point of view on findings from a prospective multicenter clinical trial of 666 patients

Cancer Medicine, 2023
Introduction With the emergence of targeted therapies, there is a need to accurately identify more tumor biomarkers. The EXOMA trial was designed to offer tumor and germline exome sequencing (ES) to patients with solid malignant tumors and facing ...
Benoit Mazel, Geoffrey Bertolone, Amandine Baurand, Elodie Cosset, Caroline Sawka, Marion Robert, Elodie Gautier, Allan Lançon, Manon Réda, Laure Favier, Valentin Dérangère, Corentin Richard, Christine Binquet, Romain Boidot, Vincent Goussot, Juliette Albuisson, François Ghiringhelli, Laurence Faivre, Sophie Nambot   +18 more
doaj   +2 more sources

FOXO1 or not FOXO1: that is the question. [PDF]

Cancer Commun (Lond)
Cancer Communications, Volume 45, Issue 1, Page 43-45, January 2025.
Marchais M, Mangeney M.
europepmc   +2 more sources

Antagonisation of Prokineticin Receptor-2 Attenuates Preeclampsia Symptoms. [PDF]

J Cell Mol Med
ABSTRACT Preeclampsia (PE) is the most threatening pathology of human pregnancy. Placenta from PE patients releases harmful factors that contribute to the exacerbation of the disease. Among these factors is the prokineticin1 (PROK1) and its receptor, PROKR2 that we identified as a mediators of PE.
Sergent F, Vaiman D, Raia-Barjat T, Younes H, Marquette C, Desseux M, Nahed RA, Kieu TL, Dung NV, Keck M, Hoffmann P, Murthi P, Benharouga M, Alfaidy N.   +13 more
europepmc   +2 more sources

The Sunrise of Tertiary Lymphoid Structures in Cancer. [PDF]

Immunol Rev
ABSTRACT First considered as a negative epiphenomenon in autoimmune and inflammatory diseases, with possible deleterious consequences through the production of pathological autoantibodies and antiself T cells, tertiary lymphoid structures (TLS) have gained major scientific and clinical interest in cancer due to their association with better clinical ...
Rochefort J, Marodon G, Teillaud JL, Dieu-Nosjean MC.   +3 more
europepmc   +2 more sources

Intrinsic cancer cell phosphoinositide 3‐kinase δ regulates fibrosis and vascular development in cholangiocarcinoma

Liver International, Volume 43, Issue 12, Page 2776-2793, December 2023., 2023
Abstract Background & Aims The class I‐ phosphatidylinositol‐3 kinases (PI3Ks) signalling is dysregulated in almost all human cancers whereas the isoform‐specific roles remain poorly investigated. We reported that the isoform δ (PI3Kδ) regulated epithelial cell polarity and plasticity and recent developments have heightened its role in hepatocellular ...
Vanessa Bou Malham, Nassima Benzoubir, Javier Vaquero, Christophe Desterke, Jean Agnetti, Pei Xuan Song, Ester Gonzalez‐Sanchez, Ander Arbelaiz, Sophie Jacques, Emanuel Di Valentin, Souad Rahmouni, Tuan Zea Tan, Didier Samuel, Jean Paul Thiery, Mylène Sebagh, Laura Fouassier, Ama Gassama‐Diagne   +16 more
wiley   +1 more source

Ebselen oxide and derivatives are new allosteric HER2 inhibitors for HER2‐positive cancers

Molecular Oncology, Volume 17, Issue 10, Page 1981-1999, October 2023., 2023
The tyrosine kinase receptor HER2 is a major oncogene in multiple cancers. We identified ebselen oxide as a new allosteric inhibitor of HER2. Ebselen oxide maintains HER2 in a catalytically repressed state by targeting the ezrin/radixin/moesin (ERM)‐binding motif in the juxtamembrane region of HER2.
Lucas Blasquez, Haniaa Bouzinba‐Segard, Sandrine Bourdoulous, Camille Faure   +3 more
wiley   +1 more source

Immunoglobulin E‐specific allergens against leaf in serum of dogs with clinical features of grass leaf allergy

Veterinary Dermatology, Volume 34, Issue 5, Page 393-403, October 2023., 2023
Background – Grass leaf has been suspected to cause immunoglobulin (Ig)E‐mediated immediate hypersensitivity reactions both in humans and in dogs. However, most studies in this area are case control studies without in vitro data showing the involvement of IgE in the reaction.
Ken Mason, Janet Davies, Merja Ruutu
wiley   +1 more source

Observing and interpreting clinical process: Methods and findings from ‘Layered analysis’ of parent–infant psychotherapy

Infant Mental Health Journal: Infancy and Early Childhood, Volume 44, Issue 5, Page 691-704, September 2023., 2023
Abstract This paper describes a method for investigating clinical process, Layered Analysis, which combines therapist countertransference reports and multi‐faceted microanalytic research approaches. Findings from the application of Layered Analysis to video‐recorded micro‐events of rupture and repair in four psychoanalytic parent–infant psychotherapy ...
Tessa Baradon, Evrinomy Avdi, Michelle Sleed, Björn Salomonsson, Keren Amiran   +4 more
wiley   +1 more source

FRUITFLYRISKMANAGE: A Euphresco project for Ceratitis capitata Wiedemann (Diptera: Tephritidae) risk management applied in some European countries

EPPO Bulletin, Volume 53, Issue 2, Page 354-371, August 2023., 2023
Abstract Ceratitis capitata (Wiedemann), the Mediterranean fruit fly or medfly, is one of the world's most serious threats to fresh fruits. It is highly polyphagous (recorded from over 300 hosts) and capable of adapting to a wide range of climates. This pest has spread to the EPPO region and is mainly present in the southern part, damaging Citrus and ...
David Lopes, Eugenia de Andrade, Alois Egartner, Francisco Beitia, Mojca Rot, Constantina Chireceanu, Valerie Balmés, Antoon Loomans, Tomasz Konefal, Sanja Radonjić   +9 more
wiley   +1 more source

Information about Climate Change Mitigation: What Do Farmers Think? Informations sur l'atténuation du changement climatique : qu'en pensent les agriculteurs? Informationen zum Klimaschutz: Was denken die Landwirtinnen und Landwirte?

EuroChoices, Volume 22, Issue 1, Page 74-80, April 2023., 2023
Summary The adoption of new practices by farmers is one of the key strategies to lower greenhouse gas (GHG) emissions from food production. In this context, effective knowledge transfer systems are essential to inform farmers about climate change, and to convince them of the benefits of new technologies. In this article, farmers’ opinions about climate
Doris Läpple
wiley   +1 more source