Results 61 to 70 of about 106,109 (302)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Carotid revascularization modality does not affect hospital contribution margin in high-risk patients

JVS-Vascular Insights
Objective: Prior clinical reports suggest that trans-carotid artery revascularization (TCAR) is less cost-effective than both carotid endarterectomy (CEA) and trans-femoral carotid artery stenting (TF-CAS).
Aaron Litvak, BA, Joel Kruger, MD, MPH, Sam Najjar, GD, Joshua Geiger, MD, MS, Adam J. Doyle, MD, Michael Stoner, MD   +5 more
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Analisis Contribution Margin Untuk Menentukan Tingkat Penjualan Produk Dalam Rangka Memaksimalkan Laba : Studi Kasus Pada PT. Pesona Remaja Malang. [PDF]

, 2008
Peningkatan volume penjualan merupakan salah satu usaha yang dilakukan perusahaan untuk memaksimalkan laba. Namun, meningkatkan volume penjualan bukanlah hal yang mudah, sehingga harus dilakukan suatu perencanaan yang baik terlebih dahulu agar ...
WiellyaKarmilaDewi
core  

MODEL ANALISIS DAMPAK PANDEMI COVID-19 TERHADAP CONTRIBUTION MARGIN USAHA KECIL MENENGAH (Studi Kasus Pada UKM Klaster Kerajinan Enceng Gondok “Klinting”, Kabupaten Semarang)

, 2022
This study aims to and analyze the extent of the impact of the COVID-19 pandemic on the Contribution Margin of Water hyacinth Handicraft UKM "Klinting Cluster" in Semarang Regency.
Karyanti, Tutik Dwi, Korawijayanti, Lardin, Widiarto, Ardian, Ciptaningtias, Arum Febriyanti   +3 more
core  

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Studi Pemberian Bakteri Asam Laktat (BAL) terhadap Persentase Lemak Abdominal dan Berat Karkas Ayam Pedaging yang Diinfeksi E.coli

Jurnal Peternakan Indonesia, 2020
Penelitian bertujuan untuk mengetahui pengaruh pemberian bakteri asam laktat (BAL) pada ayam pedaging yang diinfeksi Escherichia coli. Eksperimen ini menggunakan enam spesies bakteri (Lactobacillus casei, Lactobacillus acidophilus, Lactobacillus ...
M. R. T. Hutabarat, R. I. Pahlevy, F. Abdurrahman, D. Sibit, W. P. Lokapirnasari, K. Soepranianondo, Ardianto Ardianto   +6 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source