Results 41 to 50 of about 106,109 (302)
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Marginal fitness contributions of nonessential genes in yeast
Proceedings of the National Academy of Sciences, 1998 Analysis of the complete genome sequence of Saccharomyces cerevisiae confirms and extends earlier evidence that a majority of yeast genes are not essential, at least under laboratory conditions. Many fail to yield a discernible mutant phenotype even when disrupted.
J W, Thatcher, J M, Shaw, W J, Dickinson
openaire +3 more sources
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Analisis Contribution Margin dan Operating Laverage dalam Perencanaan Penjualan : Studi Kasus pada CV. Amarta Wisesa Malang. [PDF]
, 2008 Manajemen mempunyai beberapa fungsi pokok dalam menentukan perkembangan perusahaan, dan salah satu fungsi tersebut adalah fungsi perencanaan. Pada perusahaan multiproduk pihak manajemen harus merencanakan dan menentukan alternatif bauran produk mana
DwiRatnaKusumawati
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Jurnal Teknik Mesin, 2023 The aircraft engine shall always be checked for performance by paying attention to engine parameters and performes maintenance to maintain the condition of the aircraft.
Fikri Aulia Izzatur Rahim
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Jurnal Agrisep, 2006 The aim of the factory is to get the profit. Large or small the advantage the profit that the factory can reached out, that’s provide the management ability/succesfull in manage their company.
Redy Badrudin +2 more
doaj +1 more source
Measuring marginal risk contributions in credit portfolios [PDF]
The Journal of Computational Finance, 2005 We consider the problem of decomposing the credit risk in a portfolio into a sum of risk contributions associated with individual obligors or transactions. For some standard measures of risk – including value-at-risk and expected shortfall – the total risk can be usefully decomposed into a sum of marginal risk contributions from individual obligors ...
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Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source