Results 81 to 90 of about 4,163,984 (363)

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

A Model-Based Approach for Optimal Price Calculation of Primary Wood Products

Drvna Industrija
During a period of intensive changes in the market, when profits cannot be increased by raising sales prices, companies focus on improving production processes and reducing costs.
Andreja Pirc Barčić, Darko Motik, Stjepan Posavec, Margarita Bego, Ivana Perić   +4 more
doaj   +1 more source

The last instar larva and pupa of Ora depressa (Coleoptera: Scirtidae), a marsh beetle with underwater pupation [PDF]

, 2018
In this contribution we describe and illustrate for the first time, detailed morphology and chaetotaxy of the last instar larva and the pupa of Ora depressa (Fabricius, 1801), and provide diagnostic characters and information on its biology.
Archangelsky, Miguel, Jorge, Gabrielle, Libonatti, María Laura, Michat, Mariano Cruz   +3 more
core   +3 more sources

Contribution of the Greenland Ice Sheet to sea level over the next millennium

Science Advances, 2018
Simulations show that the Greenland Ice Sheet could disappear within a millennium if greenhouse gas emissions continue unabated. The Greenland Ice Sheet holds 7.2 m of sea level equivalent and in recent decades, rising temperatures have led to ...
A. Aschwanden, M. Fahnestock, M. Truffer, D. Brinkerhoff, R. Hock, C. Khroulev, R. Mottram, S. Khan   +7 more
semanticscholar   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Geochemistry of the Late Cretaceous Pandan Formation in Cebu Island, Central Philippines: Sediment contributions from the Australian plate margin during the Mesozoic [PDF]

, 2020
Jerali Rodrigo, Jillian Aira Gabo‐Ratio, Karlo L. Queaño, Allan G. Salazar Fernando, Leopoldo P. de Silva, Kotaro Yonezu, Yu Zhang   +6 more
openalex   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

PENGARUH COST REDUCTION TERHADAP CONTRIBUTION MARGINPERUSAHAAN : Studi Empiris Pada Perusahaan Jasa Perhotelan Yang Terdaftar Di Bursa Efek Indonesia [PDF]

, 2016
Penelitian ini bertujuan untuk mengetahui bagaimana cost reduction, contribution margin perusahaan, dan pengaruh cost reduction terhadap contribution margin perusahaan pada Perusahaan Jasa Perhotelan yang terdaftar di Bursa Efek Indonesia. Populasi dari
Gumelar, Taofik Muhammad
core