Results 81 to 90 of about 2,054,956 (265)

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Optimizing Motor Coordination in Children with Developmental Coordination Disorder: Mini-Handball vs. Motor Skills Training

Sports
Children with Developmental Coordination Disorder (DCD) experience motor competence challenges that hinder their participation in physical activities and affect daily functioning.
Hurshida Bekmanova, Orifjon Saidmamatov, Jasurbek Jammatov, Taxirbek Salayev, Raximov Quvondiq, Shikhov Gayrat, Olga Vasconcelos, Rita Barros, Claúdia Sousa, Paula Rodrigues   +9 more
doaj   +1 more source

Evaluation The Activities of Health Control Staff and Laboratories Staff for The Control of Cholera Epidemic In Al-Hilla City

Kufa Journal for Nursing Sciences, 2016
Background: Cholera is one of intestinal disease conceded life-threatening can spread rapidly of place to another and cause epidemic, affecting the population. The causative agent of cholera is gram-negative bacterium called Vibrio cholera. In 2015 Iraq
Amean A. Yasir, Haqi I. Mansoor
doaj   +1 more source

Control activities for health and hygiene requirements in National Police collective catering. [PDF]

Ital J Food Saf, 2023
Presti N, Pulze S, Ciciliano F, Vergara A.   +3 more
europepmc   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

The perceived adequacy and effectiveness of internal control activities in South African small, medium and micro enterprises

The Southern African Journal of Entrepreneurship and Small Business Management, 2019
Background: South African small, medium and micro enterprises (SMMEs) add significant socio-economic value to the national economy. Unfortunately, up to 80% of these business entities fail after being in existence for only 4 years.
Juan-Pierré Bruwer, Philna Coetzee, Jacolize Meiring   +2 more
doaj   +1 more source

The Importance of Including Non-Household Environments in Dengue Vector Control Activities. [PDF]

Viruses, 2023
Peña-García VH, Mutuku FM, Ndenga BA, Mbakaya JO, Ndire SO, Agola GA, Mutuku PS, Malumbo SL, Ng'ang'a CM, Andrews JR, Mordecai EA, LaBeaud AD.   +11 more
europepmc   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source