Results 101 to 110 of about 1,118,651 (312)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

open access: yesFEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour   +2 more
wiley   +1 more source

Novel multi-rate multicast congestion control algorithm

open access: yesTongxin xuebao, 2007
A novel congestion control mechanism based on packet-bunch probe and TCP throughput formula(PTMCC) was proposed.This receiver-driven multi-rate multicast congestion control mechanism probes available bandwidth by packet-bunch and gets TCP-friendly rate ...
ZHANG Deng-yin   +3 more
doaj   +2 more sources

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

open access: yesFEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard   +12 more
wiley   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

open access: yesFEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro   +1 more
wiley   +1 more source

Proposing an Algorithm for R&Q Inventory Control Model with Stochastic Demand Influenced by Shortage

open access: yesمدیریت تولید و عملیات, 2013
In this article, the continuous - review inventory control system has been studied. A new constraint of demand dependent on the average percent of product shortage has been added to the problem.
Parviz fattahi   +3 more
doaj  

Multiobjective PI/PID Control Design Using an Iterative Linear Matrix Inequalities Algorithm

open access: yes, 2007
Many real world control systems usually track several control objectives,simultaneously. At the moment, it is desirable to meet all specified goals using the controllers\ud with simple structures like as proportional-integral (PI) and proportional ...
Bevrani, Hassan, Hiyama, Takashi
core  

A Formulation of nonlinear model predictive control using automatic differentiation [PDF]

open access: yes, 2005
An efficient algorithm is developed to alleviate the computational burden associated with nonlinear model predictive control (NMPC). The new algorithm extends an existing algorithm for solutions of dynamic sensitivity from autonomous to non-autonomous ...
Cao, Yi
core   +1 more source

Intelligent Tutoring Systems for Adult Learning in STEM Disciplines

open access: yesNew Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Intelligent tutoring systems (ITS) are reshaping adult learning in STEM by providing adaptive, data‐driven instruction across classrooms, workplaces, and informal environments. In the context of ITS, this article compares generative AI, which creates personalized explanations and practice materials, with explainable AI, which focuses on ...
Jill Zarestky, Amanda R. Lager Gleason
wiley   +1 more source

The Pitch Control Algorithm of Wind Turbine Based on Fuzzy Control and PID Control

open access: yes, 2013
Due to the special features of great inertia, pure lag and non-linearity provided with wind turbine, coupled with complex and variable working condition, it is difficult to achieve satisfactory control results simply by employing traditional PID, which ...
Liu YY(刘意杨)   +3 more
core  

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