Results 91 to 100 of about 662,614 (319)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

A STRUCTURE APPROACH FOR A PHOTOVOLTAIC STATION CONTROL BASED ON ADAPTIVE FUZZY AGENT

open access: yesСистемный анализ и прикладная информатика, 2017
The solar energy is directly converted into electrical energy by solar PV module. Each type of PV module has its own specific characteristic corresponding to the surrounding condition such as irradiation, and temperature and this makes the tracking of ...
I. A. Elzein, Yu. N. Petrenko
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

Use of Knowledge in Selection and Control of Optimization Algorithms

open access: yes, 1987
Computers have been widely used in optimization based problem solving processes to assist with the numerical computations. The widespread availability of symbolic computational tools and recent developments in artificial intelligence now make it feasible
M. Balachandran, J.S. Gero
core  

EXPERIMENTAL RESEARCH OF THE POWER FREQUENCY TECHNOGENIC MAGNETIC FIELD ACTIVE SCREENING IN SYSTEM WITH DIFFERENT CONTROL ALGORITHMS AND WITH A SINGLE COIL

open access: yesElectrical engineering & Electromechanics, 2015
Purpose. Development of methodology and experimental studies of the layout of the active screening of technogenic power frequency magnetic fields with different control algorithms with a single coil magnetic executive body. Methodology.
B. I. Kuznetsov   +5 more
doaj  

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

Efficient and low-cost temperature automated system for aquariums in fry hatcheries using control algorithms

open access: yesRevista de Ciencias Sociales, 2023
The purpose of this research is aimed to bring an alternative solution for the raising of fry in aquatic ponds, through the control and monitoring of water temperature, in order to optimize their development and growth, regardless of the habitat where ...
Julio Macedo   +3 more
doaj  

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

On computing the zeros of periodic systems

open access: yes, 2002
We present an effcient and numerically reliable approach to compute the zeros of a periodic system. The zeros are defined in terms of the transfer-function matrix corresponding to an equivalent lifted statespace representation as constant system.
Dooren, P. Van   +6 more
core   +1 more source

Control Algorithms of Shunt Active Power Filter for Harmonics Mitigation: A Review [PDF]

open access: yes, 2017
Current harmonics is one of the most significant power quality issues which has attracted tremendous research interest. Shunt active power filter (SAPF) is the best solution to minimize harmonic contamination, but its effectiveness is strictly dependent ...
Mohd Amran Mohd Radzi   +7 more
core   +1 more source

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