Results 31 to 40 of about 200,581 (253)

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

A comparison of phase I control charts

South African Journal of Industrial Engineering, 2015
A carefully done Phase I analysis is a vital part of an overall statistical process control and monitoring regime. Distribution-free control charts can play a useful role in this analysis, as a parametric model assumption often cannot be adequately ...
Coelho, Margarethe, Chakraborti, Subhabrata, Graham, Marien Alet   +2 more
doaj   +1 more source

On the Effect of Estimation Error for the Risk-Adjusted Charts

Complexity, 2020
Control charts are a popular statistical process control (SPC) technique for monitoring to detect the unusual variations in different processes. Contrary to the classical charts, control charts have also been modified to include covariates using ...
Sajid Ali, Naila Altaf, Ismail Shah, Lichen Wang, Syed Muhammad Muslim Raza   +4 more
doaj   +1 more source

QUALITY OF SUGARCANE MECHANIZED PLANTING [PDF]

Engenharia Agrícola, 2016
: The quality of the sugarcane plantation affects the plantation longevity, yield and production costs. Therefore, this study aimed to evaluate the quality of sugarcane mechanized planting in day and night shifts.
JORGE W. CORTEZ, Camilla Missio, Ana K. G. Barreto, Marcelei D. Da Silva, Gustavo N. Dos Reis   +4 more
doaj   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Risk-Adjusted Control Charts for Health Care Monitoring

International Journal of Mathematics and Mathematical Sciences, 2011
Attribute data from high-quality processes can be monitored effectively by deciding on whether or not to stop at each time where 𝑟≥1 failures have occurred.
Willem Albers
doaj   +1 more source

Monitoring Industrial Processes with Robust Control Charts

Revstat Statistical Journal, 2009
The Shewhart control charts, used for monitoring industrial processes, are the most popular tools in Statistical Process Control (SPC). They are usually developed under the assumption of independent and normally distributed data, an assumption rarely ...
Fernanda Figueiredo , M. Ivette Gomes
doaj   +1 more source