Results 131 to 140 of about 10,114,143 (309)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Control design toolbox for large scale variable speed pitch regulated wind turbines [PDF]

, 2007
The trend towards large multi-MW wind turbineshas given new impetus to the development of wind turbine controllers.Additional objectives are being placed on the controllermaking the specification of the control system more complex.
Dominguez, S., Leithead, W.E.
core  

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Development and Optimization of ¹¹C-Labeled Radiotracers: A Review of the Modern Quality Control Design Process. [PDF]

ACS Pharmacol Transl Sci, 2023
Myburgh PJ, Sai KKS.
europepmc   +1 more source

Multi-objective design of robust flight control systems [PDF]

, 2008
A multi–objective evolutionary algorithm is used in the framework of H1 control theory to find the controller gains that minimize a weighted combination of the infinite–norm of the sensitivity function (for disturbance attenuation requirements) and ...
Avanzini, G., D'Angelo, S., Dutto, M., Minisci, E.A.   +3 more
core  

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Study on correction technology of aircraft angle-of-attack signal based on estimation of side-slip angle

Hangkong gongcheng jinzhan
The angle-of-attack signal is very important for modern fly-by-wire flight control system aircraft. The inconsistency of the local airflow on both sides of the nose will cause the difference of the angle-of-attack signal.The signal-monitoring voting ...
XUE Yuan, LIU Shimin, WEI Jianlong
doaj   +1 more source

BASIC: A Bayesian adaptive synthetic-control design for phase II clinical trials. [PDF]

Clin Trials, 2023
Jiang L, Thall PF, Yan F, Kopetz S, Yuan Y.   +4 more
europepmc   +1 more source