Results 191 to 200 of about 1,142,441 (317)

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Dispersion engineering by rotational symmetry breaking in an optical microcavity. [PDF]

Light Sci Appl
Ren JZ, Li LJ, Zhang RQ, Wang ZY, Cao QT, Xiao YF.   +5 more
europepmc   +1 more source

Insight Engines im Controlling

Controlling & Management Review, 2020
openaire   +1 more source

A study about the application of artificial intelligence and software engineering techniques to the implementation of a supervision and control system

, 2007
Leticia Toledo Maia
openalex   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

A Novel Technique for Quality Control of Microinjection Molding. [PDF]

Micromachines (Basel)
Daoud AN, Ghaleb AM, Ali Z, Abdelhafeez Hassan A.   +3 more
europepmc   +1 more source

Engineering Control of Occupational Diseases [PDF]

American Journal of Public Health and the Nations Health, 1935
openaire   +2 more sources

Editorial: Evolution mechanism and control method of engineering disasters under complex environment [PDF]

Jianyong Han, Hai Li, Xiaoyu Bai, Zhongqiang Liu, Jae-Joon Song, Pengjiao Jia   +5 more
openalex   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Correction: A hybrid approach for regionalization of precipitation based on maximal discrete wavelet transform and growing neural gas network clustering. [PDF]

Sci Rep
Tao X, Ben M, Xuan HCY, Arshaghi A.
europepmc   +1 more source