Results 61 to 70 of about 4,596,428 (351)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Embedded Software Design for Mechatronic Systems [PDF]

, 2003
This research project is motivated by the fact that nowadays it is impossible to separate control engineering from software engineering. Besides that both of them can be found in definitions of mechatronics, this project deals with exploitation and ...
Broenink, Jan F., Hilderink, Gerald H., Jovanovic, Dusko   +2 more
core   +1 more source

On Learning Machines for Engine Control [PDF]

, 2008
The chapter deals with neural networks and learning machines for engine control applications, particularly in modeling for control. In the first section, some basics on the common features of engine control are recalled, based on a layered engine management structure. Then the use of neural networks for engine modeling, control and diagnosis is briefly
Bloch, Gérard, Lauer, Fabien, Colin, Guillaume   +2 more
openaire   +2 more sources

Retracted: Remote Control and Fault Diagnosis of Port Mechanical Equipment Based on Wireless Communication Technology

Journal of Control Science and Engineering, 2023
Journal of Control Science and Engineering
doaj   +1 more source

Group Design Project in Control Engineering: Adapting to COVID-19 Pandemic. [PDF]

IFAC Pap OnLine, 2021
Ignatyev DI, Shin HS, Zolotas A, Tsourdos A.   +3 more
europepmc   +1 more source

Technical management techniques for identification and control of industrial safety and pollution hazards [PDF]

, 1972
Constructive recommendations are suggested for pollution problems from offshore energy resources industries on outer continental shelf. Technical management techniques for pollution identification and control offer possible applications to space ...
Campbell, R., Dyer, M. K., Hoard, E. G., Little, D. G., Taylor, A. C.   +4 more
core   +1 more source