Results 131 to 140 of about 806,809 (312)

Biological systems thinking for control engineering design

, 2003
Artificial neural networks and genetic algorithms are often quoted in discussions about the contribution of biological systems thinking in engineering design.
D. J. Murray-Smith, Murray-Smith, DJ, Murray-Smith, D. J., Murray-Smith, D.J.   +3 more
core   +1 more source

Systems and control in transportation engineering

Systems Science & Control Engineering, 2018
Qiankun Song, Bing Li, Huiwei Wang
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Advanced Undersea Warfare Systems [PDF]

, 2011
Includes supplementary materialOver the next twenty years, the proliferation of threats in the undersea environment will likely challenge the platform-centric model that the United States Navy uses to maintain dominance in Undersea Warfare (USW ...
Drennan, Jim, Daniel, Perh Hong Yih, Lun, Sor Wei, Kiong, Teo Yong, Walker, William, Chuan, Ng Kiang, Wessner, Wes, Saburn, Jon, Heng, Wong Chee, Wei, Chang Chung, Chiam, David, Kok, Pek Wee, Chuan, Wee Hong, SEA Cohort SEA-17B, Yung, Koh Wee, Harvey, Scott, Malinowski, Matt, Emmersen, Tracy, Castaneda, Phil, Liang, Lu Zheng, Mills, Thomas, Zhu, Kelvin, Xuan, Ong Zi, Wee, Lim Choon, Fung, Tan Yick, Silvestrini, Christian   +25 more
core  

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Genetic Algorithms in Control Systems Engineering [PDF]

, 2001
Genetic algorithms (GA'S) are global, parallel, stochastic search methods, founded on Darwinian evolutionary principles. Many variations exist, including genetic programming and multi-objective algorithms. During the last decade GA's have been applied in
Fleming, P.J., Pursehouse , R.C.
core  

Consensus-Based Coordination and Control for Building Automation Systems

, 2015
This brief presents coordination and control for heating energy distribution in building automation systems. Building thermal networks consist of rooms that are interconnected through communication and physical heat transfer networks.
Ahn, Hyo-Sung, Kim, Byeong-Yeon
core   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Universal Adaptive Control of Nonlinear Systems

This letter develops a new direct adaptive control framework that extends the certainty equivalence principle to general nonlinear systems with unmatched model uncertainties.
Slotine, Jean-Jacques E., Lopez, Brett T.   +1 more
core   +1 more source