Results 51 to 60 of about 642,378 (311)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Internal and external disturbances aware motion planning and control for quadrotors

IET Cyber-systems and Robotics
Resilient motion planning and control, without prior knowledge of disturbances, are crucial to ensure the safe and robust flight of quadrotors. The development of a motion planning and control architecture for quadrotors, considering both internal and ...
Xiaobin Zhou, Miao Wang, Can Cui, Yongchao Wang, Chao Xu, Fei Gao   +5 more
doaj   +1 more source

Modelling and practical studying of heat recovery steam generator (HRSG) drum dynamics and approach point effect on control valves

Ain Shams Engineering Journal, 2018
In this paper, we present a simple procedure to build a model of a heat recovery steam generator (HRSG) evaporator and drum within the environment of MATLAB/Simulink. The HRSG is part of combined cycle power plant that is located at Talkha power station (
Ahmed Shams El-din Ahmed, Mostafa A. Elhosseini, Hesham Arafat Ali   +2 more
doaj   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Control Method of Complex Environmental Engineering Machinery Cooling System Integrating Deep Learning and Feature Clustering [PDF]

, 2021

openalex   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Design of Nonlinear PID and FOPID Controllers for Electronic Throttle Valve Plate’s Position

Journal of Electrical and Computer Engineering
The electronic throttle valve (ETV) system is one of the essential parts of the automobile because it controls the amount of airflow into the engine’s combustion system. In fact, there are challenges in ETV control due to several nonsmooth nonlinearities,
Mohamed Jasim Mohamed, Luay Thamir Rasheed   +1 more
doaj   +1 more source

Teaching System Modeling and Feedback Control Systems: A Multidisciplinary Course in Mechanical Engineering and Electrical Engineering [PDF]

, 2020
Li Tan, Jean Jiang
openalex   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source