Results 51 to 60 of about 3,374,155 (295)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Quantum control in infinite dimensions

open access: yes, 2003
Accurate control of quantum evolution is an essential requirement for quantum state engineering, laser chemistry, quantum information and quantum computing.
Ball   +7 more
core   +2 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

An Advanced Helicopter Engine Control System [PDF]

open access: yesAircraft Engineering and Aerospace Technology, 1982
The Amalgamation of Functions The requirements of the first engine controllers were primarily to satisfy the needs of the engine and, almost as an afterthought, to consider interface with the aircraft and the pilot. The latter resulted in the overwhelming plethora of “essential” ground test‐sets and cockpit instruments that we see today.
openaire   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Integral Sliding Mode Control Design for Electronic Throttle Valve System

open access: yesAl-Khawarizmi Engineering Journal, 2015
One of the major components in an automobile engine is the throttle valve part. It is used to keep up with emissions and fuel efficiency low. Design a control system to the throttle valve is newly common requirement trend in automotive technology.
Shibly Ahmed AL-Samarraie   +2 more
doaj   +4 more sources

Design of Integral Sliding Mode Controller for Servo DC Motor

open access: yesمجلة النهرين للعلوم الهندسية, 2017
DC servo motor is simple in construction and control and has many applications. However, the uncertainties due to its parameters changes such as load torque and friction are an evitable.
Bashar Fateh Midhat   +2 more
doaj  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Dynamics of ion sound waves in the front of the terrestrial bow shock [PDF]

open access: yesAnnales Geophysicae, 2011
Single spacecraft measurements from the Cluster 3 satellite are used to identify nonlinear processes in ion-sound turbulence observed within the front of the quasiperpendicular terrestrial bow shock. Ion sound waves possess spatial scales that are too
I. Giagkiozis   +2 more
doaj   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

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