Results 31 to 40 of about 12,023,497 (300)

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

SURGICAL TREATMENT OF TUBERCULOSIS IN HIV PATIENTS

Туберкулез и болезни лёгких, 2018
The objective of the study: to study the outcomes of surgical treatment of tuberculosis in HIV patients.Subjects and methods. Surgery outcomes in 345 HIV patients with respiratory tuberculosis were analyzed; totally, 355 surgeries were performed on them.
Mikhail V. Sinitsyn, Nikolay Yu. Virskiy, Marina V. Tityukhina, Boris G. Barskiy, Tamila I. Abu Arkub, Marina V. Kalinina   +5 more
doaj   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

Comparative Effectiveness and Safety of Inebilizumab Versus Rituximab in AQP4‐IgG‐Positive NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rituximab (anti‐CD20, RTX) and inebilizumab (anti‐CD19, INE) represent B‐cell‐depleting therapies used for aquaporin‐4 antibody‐positive (AQP4‐IgG+) neuromyelitis optica spectrum disorder (NMOSD); however, direct comparative evidence remains limited.
Jie Lin, Binbin Xue, Dewei Xie, Jia Li, Juyuan Pan, Lanbing Zhu, Qiaowen Tong, Jing Lin, Ruofan Zhu, Xu Zhang, Junhui Xia, Xiang Li   +11 more
wiley   +1 more source

Nationwide Survey of Association Between Fever and Epileptic Seizure in CDKL5 Deficiency Disorder Revealed Therapeutic Implications

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective CDKL5 deficiency disorder (CDD) is a rare, severe developmental and epileptic encephalopathy. There is a pressing need to develop effective and sustainable therapeutic strategies. We aimed to investigate the causal association between febrile episodes and epileptic seizures for therapeutic implications in CDD patients.
Siyi Wang, Jialin Du, Jinghui Liu, Dongmei Hu, Hongxin Wang, Xiaoxiao Man, Lehong Gao, Shimin Hu, Xianghong Meng, Hongyang Zhao, Minjing Hu, Yingxue Yang, Zhiqi Xiong, Liankun Ren   +13 more
wiley   +1 more source

El control preventivo de la hacienda pública municipal en la provincia de Entre Ríos [PDF]

, 2019
Este trabajo reseña el modelo de control preventivo de los actos administrativos relacionados mediata o inmediatamente con la hacienda pública de los municipios de Entre Ríos.
Cosundino, Roberto A.
core   +1 more source

Clinical Impact of MGMT Promoter Methylation in IDH‐Mutant Gliomas: Influence of Threshold Selection and Clinical Confounding

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background The clinical relevance of MGMT promoter methylation in IDH‐mutant gliomas remains controversial in the era of molecular classification. We aimed to systematically evaluate its clinical relevance by integrating quantitative assessment, cutoff exploration, and adjustment for clinical confounding.
Haihui Jiang, Linxi Cao, Xiaodong Chen, Siqi Tong, Qinghui Zhu, Jun Yang, Song Lin, Yong Cui   +7 more
wiley   +1 more source

Segregació escolar, equitat i inclusió : informe de la Comissió de Treball del Consell Educatiu Municipal de Barcelona [PDF]

, 2020
Forma part de la col·lecció: Quaderns del Consell Educatiu Municipal de ...
Consell Educatiu Municipal de Barcelona, Institut Municipal d'Educació (Barcelona)   +1 more
core   +1 more source

Nrf-2/HO-1 activation protects against oxidative stress and inflammation induced by metal welding fume UFPs in 16HBE cells

Scientific Reports
As one of the main occupational hazards, welding fumes can cause oxidative damage and induce series of diseases, such as COPD or asthma. To clarify the effects of the metal fume ultrafine particulates (MF-UFPs) of welding fumes on oxidative damage, UFPs ...
Mengchao Ying, Yun Yang, Qian Huo, Jingqiu Sun, Xinyu Hong, Feng Yang, Yamin Fang, Lingyi Lu, Tingfeng Mao, Ping Xiao, Gonghua Tao   +10 more
doaj   +1 more source

Contamination of reusable cleaning tools in healthcare settings: a study based on the longitudinal surveillance in Shanghai

Frontiers in Public Health
BackgroundHealthcare-associated infections (HAIs) have become global public health threat to human health. Contaminated hospital environments are increasingly recognized as critical reservoirs and vectors in the transmission of HAIs.
Xing Zhang, Lyulan Huang, Junhua Fan, Xiaofan Ji, Yilin Ge, Taiyao Chen, Jing Bi, Tingting Shi, Renyi Zhu, Liang Tian, Jian Chen   +10 more
doaj   +1 more source