Results 121 to 130 of about 3,393,140 (353)
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Editorial: Immune intervention avenues to control fungal infections in immunocompromised individuals. [PDF]
Front Immunol, 2023 Nanjappa SG.
europepmc +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Updates on the Virulence Factors Produced by Multidrug-Resistant Enterobacterales and Strategies to Control Their Infections. [PDF]
Microorganisms, 2023 Azam MW, Zarrilli R, Khan AU.
europepmc +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
TÉCNICA DE HIGIENIZAÇÃO SIMPLES DAS MÃOS: A PRÁTICA ENTRE ACADÊMICOS DA ENFERMAGEM
Ciencia y EnfermeríaEstudo realizado com graduandos de enfermagem do último ano/semestre de Instituições de Ensino Superior (IES) em Goiás no período de 2005 e 2006, com objetivo de avaliar a técnica de higienização das Mãos (HM) descrita por graduandos de enfermagem e ...
Anaclara Ferreira Veiga Tipple +4 more
doaj +1 more source
Bites from the same dog, different outcomes for two patients: a case report
Infectious Diseases of Poverty, 2017 Background Rabies is a serious reemerging zoonosis in China. At present human rabies cases are primarily diagnosed based on clinical presentation. Case presentation In August 2012, a woman and her son were attacked by a stray dog in Henan, China. The son
Xue-Yong Huang +6 more
doaj +1 more source
Editorial: Fighting fire with fire: Using non-pathogenic viruses to control unrelated infections. [PDF]
Front Immunol, 2022 Bakacs T +3 more
europepmc +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Total Failure of Fenbendazole to Control Strongylid Infections in Czech Horse Operations. [PDF]
Front Vet Sci, 2022 Nápravníková J +2 more
europepmc +1 more source