Results 131 to 140 of about 168,817,331 (301)

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Vancomycin-Resistant Enterococci (VRE) in Canada – Results of the Canadian Nosocomial Infection Surveillance Program 1996 VRE Point Prevalence Surveillance Project

Canadian Journal of Infectious Diseases, 1997
Marianna Elisabeth Ofner-Agostini, John Conly, Shirley Paton, Amar Kureishi, Lindsay Nicolle, Michael Mulvey, Wendy Johnson, Lynn Johnston, the Canadian Hospital Epidemiology Committee   +8 more
doaj   +1 more source

Report of the Board of Control: 1920. [PDF]

, 1920
Report of the Board of Control 1920 issue. The report serial gives financial reports, including budgetary requests and recommendations for the state institutions under the management of the Board, beginning with University of Florida, Florida State ...
Florida. Board of Control,
core  

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Immunofluorescence analysis reveals no increased seroprevalence of anti-Bartonella schoenbuchensis-IgG antibodies in German forest workers

Parasites & Vectors
Background Bartonella schoenbuchensis is suspected to cause deer ked dermatitis and febrile diseases in humans. Deer keds (Lipoptena cervi), which infest cervids (e.g., roe deer, fallow deer), are discussed as potential vectors for B.
Kim Nina Buntrock, Wibke Ballhorn, Heike Podlich, Johan Malmström, Lotta Happonen, Sounak Chowdhury, Annette Jurke, Volkhard A. J. Kempf   +7 more
doaj   +1 more source

Report of the Board of Control: 1938. [PDF]

, 1938
Report of the Board of Control 1938 issue. The report serial gives financial reports, including budgetary requests and recommendations for the state institutions under the management of the Board, beginning with University of Florida, Florida State ...
Florida. Board of Control,
core  

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Report of the Board of Control: 1940. [PDF]

, 1940
Report of the Board of Control 1940 issue. The report serial gives financial reports, including budgetary requests and recommendations for the state institutions under the management of the Board, beginning with University of Florida, Florida State ...
Florida. Board of Control,
core  

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source