Results 141 to 150 of about 167,930,433 (313)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Nonlinear control systems, design methods

, 1999
The sections in this article are: The Regulation Problem, Linear Time-Invariant Systems,Feedback Linearization, Passivity-Based Control, Control Under Model and Parameter Uncertainties, Third-Order Feedback Linearizable Systems, Conclusion ...
Webster, J.G., Loria, A., Nijmeijer, H.
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

System for controlled mechanical therapies of the brain

Ultrasonics
Transcranial focused ultrasound enables remote targeted therapies that were previously only possible using surgical approaches. Mechanical therapies are particularly attractive due to their confined action and the elimination of the potentially harmful tissue and skull heating. However, systems for controlled mechanical therapies of the brain have been
Eli Finlinson, Matt Snyder, Tom Riis, Jan Kubanek   +3 more
openaire   +2 more sources

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Completeness of Riemannian Metrics: An Application to the Control of Constrained Mechanical Systems

© 2025 The Authors. This work is licensed under a Creative Commons Attribution 4.0 License. For more information, see http://creativecommons.org/licenses/by/4.0/We introduce a mathematical technique based on modifying a given Riemannian metric and we ...
Bloch, Anthony, Martín de Diego, David, Acosta Rodríguez, José Ángel   +2 more
core   +1 more source

Control for Societal-scale Challenges: Road Map 2030

, 2023
The world faces some of its greatest challenges of modern time and how we address them will have a dramatic impact on the life for generations to come.
Murray, Richard, Parisini, Thomas, Kuh, Anthony, Hespanha, João P., Pavone, Marco, Burdick, Joel, Ishii, Hideaki, Khammash, Mustafa, Ranade, Gireeja, Pappas, George J., Schenato, Luca, Franco, Elisa, Ames, Aaron D., Filev, Dimitar, Annaswamy, Anuradha M., Balakrishnan, Hamsa, Bogdan, Paul, Dahleh, Munther, Jadbabaie, Ali, Sandberg, Henrik, Johansson, Karl H., Como, Giacomo, Rajhans, Akshay, Sreenath, Koushil, Das, Amritam, Bullo, Francesco, Dragan, Anca, Allgöwer, Frank, Gayme, Dennice, How, Jonathan P., Tegling, Emma, Netto, Mariana, Mareels, Iven, Bagheri, Neda, Scherpen, Jacquelien, Sepulchre, Rodolphe, Amin, Saurabh, Di Cairano, Stefano, Menara, Tommaso, O’Malley, Marcia K., Bamieh, Bassam, Bayen, Alexandre, Johansen, Tor, Lygeros, John, Shamma, Jeff, Ratliff, Lillian, Rossiter, J. Anthony, Pasqualetti, Fabio, Fujita, Masayuki, Fay, Sarah, Egerstedt, Magnus, Stoustrup, Jakob, Sarma, Sri, Chakrabortty, Aranya, Dassau, Eyal, Tilbury, Dawn, Samad, Tariq, Bauer, Margret, Nedich, Angelia, Alleyne, Andrew, Jafarian, Matin, Csete, Marie, Mombaur, Katja, Hosoi, Anette, Dörfler, Florian, Work, Dan, Lamnabhi-Lagarrigue, Françoise, Neema, Sandeep, Krause, Andreas, Tomlin, Claire J., Sinopoli, Bruno, Kulić, Dana, Moore, Kevin, Pao, Lucy Y., Dimarogonas, Dimos, Schoellig, Angela, Cassandras, Christos G., Hug, Gabriela, Matni, Nikolai, Baras, John, Fontan, Angela, De Persis, Claudio, Leonard, Naomi E., Heemels, W.P.M.H., Tabuada, Paulo, Wise, Kevin, Rantzer, Anders, Shorten, Robert, Zeilinger, Melanie, Leve, Frederick, Sadigh, Dorsa, Cao, Ming, Papachristodoulou, Antonis, Doyle, John C., Brunton, Steven L., Eker, Johan, Burlion, Laurent, Burdet, Etienne, O’Leary, Timothy, Antsaklis, Panos J., Qing-Shan Jia, Samuel, Canudas de Wit, Carlos, Li, Na, Ilić, Marija, Khargonekar, Pramod, di Bernardo, Mario, Garcia-Sanz, Mario, Dabbene, Fabrizio, Tumova, Jana, Zafar, Junaid, Doyle III, Francis J., Namerikawa, Toru, Martinez, Sonia, Anderson, James, Kochenderfer, Mykel J., Paré, Philip E., Sun, Jing, Hirche, Sandra, Jones, Dalton, Low, Steven   +119 more
core