Results 121 to 130 of about 1,852,802 (292)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

A Control and Management Plane for Large Packet Switches [PDF]

, 2008
Bianco, Andrea, Finochietto, J.M., Gavilanes, G., Neri, Fabio   +3 more
core   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Sensorless Predictive Multiscalar-Based Control of the Five-Phase IPMSM

IEEE Access
This article proposes multi-scalar variables based predictive control of sensorless multiphase interior permanent magnet synchronous machine. Estimated parameters from adaptive observers are used to implement the proposed control scheme.
Deepak Vyas, Marcin Morawiec, Grzegorz Kostro, Andrzej JaDerko, Janusz Baran   +4 more
doaj   +1 more source

Integrated Management of Network Address Translation, Mobility and Security on the Blockchain Control Plane. [PDF]

Sensors (Basel), 2019
Jung Y, Agulto R.
europepmc   +1 more source

Aircraft digital control design methods [PDF]

Variations in design methods for aircraft digital flight control are evaluated and compared. The methods fall into two categories; those where the design is done in the continuous domain (or s plane) and those where the design is done in the discrete ...
Parsons, E., Powell, J. D., Tashker, M. G.   +2 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Cluster-Based Control Plane Messages Management in Software-Defined Flying Ad-Hoc Network. [PDF]

Sensors (Basel), 2019
Cumino P, Maciel K, Tavares T, Oliveira H, Rosário D, Cerqueira E.   +5 more
europepmc   +1 more source

Strong practical stability based robust stabilization of uncertain discrete linear repetitive processes

, 2013
Repetitive processes are a distinct class of 2D systems of both theoretical and practical interest whose dynamics evolve over a subset of the positive quadrant in the 2D plane. The stability theory for these processes originally consisted of two distinct
Bachelier, O, Dabkowski, P, Galkowski, K, Kummert, A, Lam, J, Rogers, E   +5 more
core  

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source