Results 71 to 80 of about 3,051,873 (249)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Phylogeographic study of brown trout from Serbia, based on mitochondrial DNA control region analysis

Genetics Selection Evolution, 2006
In order to illuminate the phylogeography of brown trout (Salmo trutta) populations in the Balkan state of Serbia, the 561 bp 5'-end of mtDNA control region of 101 individuals originating from upland tributaries of the Danubian, Aegean and Adriatic ...
Snoj Aleš, Simonović Predrag, Sušnik Simona, Marić Saša   +3 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Long—term atmosphere surveillance (2017–2022) of PM2.5‑bound polycyclic aromatic hydrocarbons and health risk assessment in a typical city in northern China

BMC Public Health
Objective By analyzing the pollution characteristics of polycyclic aromatic hydrocarbons (PAHs) in PM2.5 in the atmosphere of Hohhot City, we can assess their main sources and evaluate their health hazards.
Duo-duo Wu, Na-na Wei, Chen-guang Zhang, Xuan-zhi Yue, Huan Li, Wen-yu Zhang, Xin-rui Jia, Jia-ke Zhu, Wen-qian Zhang, Yao-chun Fan, Sheng-mei Yang   +10 more
doaj   +1 more source

Mitochondrial DNA Variation Reveals a Sharp Genetic Break within the Distribution of the Blue Land Crab Cardisoma guanhumi in the Western Central Atlantic

Molecules, 2015
The blue land crab Cardisoma guanhumi is widely distributed throughout tropical and subtropical estuarine regions in the Western Central Atlantic (WCA). Patterns of population genetic structure and historical demographics of the species were assessed by ...
Maria Rosimere Xavier Amaral, Marc Albrecht, Alan Shane McKinley, Adriana Márcia Ferreira de Carvalho, Severino Cavalcante de Sousa, Fabio Mendonça Diniz   +5 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Epidemiological characteristics and incidence prediction analysis of brucellosis in Bayingolin mongol autonomous prefecture, Xinjiang

BMC Infectious Diseases
Background Brucellosis remains endemic in the Bayingolin Mongol Autonomous Prefecture (Bayingolin Prefecture), posing a dual threat to public health and the livestock economy.
Jiuchen Ke, Long Zhang, Xuehui Cao, Yimei Xu, Haibo He, Adili Simayi, Jun Wu, Jiangshan Zhao   +7 more
doaj   +1 more source