Results 91 to 100 of about 17,598,917 (302)

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Infection prevention and control risk factors in health workers infected with SARS-CoV-2 in Jordan: A case control study. [PDF]

PLoS One, 2022
Tarif AB, Ramadan M, Yin M, Sharkas G, Ali SS, Gazo M, Zeitawy A, Alsawalha L, Wu K, Alonso-Garbayo A, Zayed B, Al-Ariqi L, Kheirallah KA, Talaat M, Rashidian A, Simniceanu A, Allegranzi B, Cassini A, Bellizzi S.   +18 more
europepmc   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Assessment of intervention measures on trihalomethane in finished water by interrupted time series analysis

环境与职业医学
BackgroundThe Qingcaosha Reservoir is facing issues of algal blooms and eutrophication, and the resulting increase in the level of chlorination disinfection by-products in the water has been a major concern.
Yangyang REN, Hailei QIAN, Saifeng PEI, Xiaodong SUN, Zheng WU, Chen WU, Jingxian ZHOU, Aimin DU, Shaofeng SUI   +8 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Reducing the Risk of Healthcare Associated Infections from Legionella and Other Waterborne Pathogens Using a Water Management for Construction (WMC) Infection Control Risk Assessment (ICRA) Tool. [PDF]

Infect Dis Rep, 2022
Scanlon MM, Gordon JL, Tonozzi AA, Griffin SC.   +3 more
europepmc   +1 more source

Risk and risk perception: the metropolitan imaginary of catastrophe at the time of the Covid-19

, 2021
The Covid-19 health emergency takes place in the list of “new risks” that punctuate the scene of the “world risk society” (Beck, 2011). This state of affairs, characterized by the worsening of the feeling of uncertainty and anguish, finds its raison d ...
Elena SAVONA
core  

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Cohort Profile: The Iodine Status in Pregnancy and Offspring Health Cohort (ISPOHC)

Journal of Epidemiology
The Iodine Status in Pregnancy and Offspring Health Cohort (ISPOHC) was initiated in Shanghai to address the need for a comprehensive and longitudinal study on iodine nutrition and its effects on maternal and offspring health.
Zhuo Sun, Huiting Yu, YiXian Li, Wei Lu, Zhengyuan Wang, Qi Song, Shupeng Mai, Zehuan Shi, Liping Shen, Wenqing Ma, Xin Cui, Chen Xin, Jiajie Zang   +12 more
doaj   +1 more source

Atrial thrombi in elective patients considered for atrial fibrillation rhythm control: Risk factors and prognostic value. [PDF]

Indian Heart J, 2021
Caires MC, Ferreira RM, Rodrigues TF, Kang DH, Salis LHA, de Souza E Silva NA.   +5 more
europepmc   +1 more source