Results 81 to 90 of about 3,308,479 (319)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Total α and β radioactivity levels of source water in two areas of Shanghai from 2012 to 2022

Shanghai yufang yixue
ObjectiveThe purpose was to understand the background level of environmental radioactivity in the surrounding area of Qinshan Nuclear Power Plant and accumulate historical monitoring data of radioactivity in the environment， in order to detect and deal ...
HUANG Minpeng, QIAN Aijun, LUO Fajian, GAO Linfeng   +3 more
doaj   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Reducing the Risk of Healthcare Associated Infections from Legionella and Other Waterborne Pathogens Using a Water Management for Construction (WMC) Infection Control Risk Assessment (ICRA) Tool. [PDF]

Infect Dis Rep, 2022
Scanlon MM, Gordon JL, Tonozzi AA, Griffin SC.   +3 more
europepmc   +1 more source

Relationship between bone mineral density and fragility fracture risk: a case-control study in Changsha, China [PDF]

, 2021
Hongli Li, Yi Shen, Lihua Tan, Songbo Fu, Ru-Chun Dai, Ling‐Qing Yuan, Zhifeng Sheng, Zhongjian Xie, Xian-Ping Wu, Ling‐Qing Yuan, Xulei Tang, Xi‐Yu Wu   +11 more
openalex   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Advanced redox flow fuel cell using ferric chloride as main catalyst for complete conversion from carbohydrates to electricity

Scientific Reports, 2017
Liquid catalyzed fuel cell (LCFC) is a kind of redox flow fuel cell directly converting carbohydrates to electricity. To improve its efficiency, ferric chloride (FeCl3) was introduced as main catalyst.
Fan Xu, Huan Li, Yueling Liu, Qi Jing
doaj   +1 more source

Atrial thrombi in elective patients considered for atrial fibrillation rhythm control: Risk factors and prognostic value. [PDF]

Indian Heart J, 2021
Caires MC, Ferreira RM, Rodrigues TF, Kang DH, Salis LHA, de Souza E Silva NA.   +5 more
europepmc   +1 more source

Avocado Consumption for 12 Weeks and Cardiometabolic Risk Factors: A Randomized Controlled Trial in Adults with Overweight or Obesity and Insulin Resistance [PDF]

, 2022
Xuhuiqun Zhang, Di Xiao, Gabriela Maldonado Guzmán, Indika Edirisinghe, Britt Burton‐Freeman   +4 more
openalex   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source