Results 81 to 90 of about 3,393,482 (319)

Upacicalcet: A Novel Intravenous Calcimimetic Agent for Patients Undergoing Hemodialysis With Secondary Hyperparathyroidism

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Secondary hyperparathyroidism (SHPT) is a common complication in patients receiving maintenance dialysis, driven by calcium and phosphate metabolism disturbances. Calcimimetics are central to the management of SHPT by enhancing calcium‐sensing receptor sensitivity and reducing parathyroid hormone secretion.
Fumihiko Koiwa, Daisuke Honda, Seigo Akari, Tadao Akizawa   +3 more
wiley   +1 more source

Assessment of intervention measures on trihalomethane in finished water by interrupted time series analysis

环境与职业医学
BackgroundThe Qingcaosha Reservoir is facing issues of algal blooms and eutrophication, and the resulting increase in the level of chlorination disinfection by-products in the water has been a major concern.
Yangyang REN, Hailei QIAN, Saifeng PEI, Xiaodong SUN, Zheng WU, Chen WU, Jingxian ZHOU, Aimin DU, Shaofeng SUI   +8 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Inadequate control of atherosclerotic cardiovascular disease risk factors in Europe: EUROASPIRE repeats itself [PDF]

, 2019
Raúl D. Santos
openalex   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Cohort Profile: The Iodine Status in Pregnancy and Offspring Health Cohort (ISPOHC)

Journal of Epidemiology
The Iodine Status in Pregnancy and Offspring Health Cohort (ISPOHC) was initiated in Shanghai to address the need for a comprehensive and longitudinal study on iodine nutrition and its effects on maternal and offspring health.
Zhuo Sun, Huiting Yu, YiXian Li, Wei Lu, Zhengyuan Wang, Qi Song, Shupeng Mai, Zehuan Shi, Liping Shen, Wenqing Ma, Xin Cui, Chen Xin, Jiajie Zang   +12 more
doaj   +1 more source

Effect of bromocriptine on glycemic control, risk of cardiovascular diseases and weight in patients with type 2 diabetes: a systematic review. [PDF]

Diabetol Metab Syndr, 2023
Birhan MT, Ayele TM, Abebe FW, Dgnew FN.
europepmc   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Measurement errors in control risk regression: A comparison of correction techniques. [PDF]

Stat Med, 2022
Guolo A.
europepmc   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source