Results 151 to 160 of about 5,029,247 (317)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Distributionally Robust Optimization Adaptive Event‐Triggered SMPC for DC‐DC Converters Subject to Unknown Disturbances and DoS Attacks

IET Power Electronics
In this paper, we present adaptive event‐triggered distributionally robust optimization stochastic model predictive control (AET‐DROSMPC) applied to DC‐DC converters subject to unknown disturbances and denial of service (DoS) attacks.
Yadong Chen, Peng Cheng
doaj   +1 more source

Review of barriers to the introduction of residential demand response: A case study in the Netherlands

, 2017
Demand response, defined as the shifting of electricity demand, is generally believed to have value both for the grid and for the market: by matching demand more closely to supply, consumers could profit from lower prices, while in a smart grid ...
van Sark, W. G J H M, Energy System Analysis, Energy and Resources, van Hooff, J., Weck, M. H J   +4 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

A sliding mode‐based single‐loop control strategy for permanent magnet synchronous motor drives

IET Power Electronics
A simple control structure with high anti‐disturbance ability is proposed here for permanent magnet synchronous motor (PMSM) drives. The conventional cascade structure, with an outer speed loop and an inner current loop, is simplified and merged into one
Thanh‐Lam Le, Min‐Fu Hsieh
doaj   +1 more source

Control of quantum stochastic differential equations [PDF]

, 2005
We review the basic features of the quantum stochastic calculus. Iteration schemes for the computation of the matrix elements of solutions of unitary quantum stochastic evolutions and associated quantum flows are provided along with a basic error ...
Accardi, L, Boukas, A., Boukas, A, ACCARDI, LUIGI   +3 more
core  

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Closed‐loop stability analysis of deep reinforcement learning controlled systems with experimental validation

IET Control Theory & Applications
Trained deep reinforcement learning (DRL) based controllers can effectively control dynamic systems where classical controllers can be ineffective and difficult to tune.
Mohammed Basheer Mohiuddin, Igor Boiko, Rana Azzam, Yahya Zweiri   +3 more
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source