Results 91 to 100 of about 5,893,645 (283)

Optimal Control Theory for Undergraduates [PDF]

Dynamic optimization is widely used in financial economics, macroeconomics and resource economics. This is accounting for some tension between the undergraduate and graduate teaching of economics because most undergraduate programs still concentrate on ...
Ernst Juerg Weber
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

How synaptic function controls critical transitions in spiking neuron networks: insight from a Kuramoto model reduction

Frontiers in Network Physiology
The dynamics of synaptic interactions within spiking neuron networks play a fundamental role in shaping emergent collective behavior. This paper studies a finite-size network of quadratic integrate-and-fire neurons interconnected via a general synaptic ...
Lev A. Smirnov, Vyacheslav O. Munyayev, Maxim I. Bolotov, Grigory V. Osipov, Igor Belykh   +4 more
doaj   +1 more source

A Method to Monitor IGBT Module Bond Wire Failure Using On-State Voltage Separation Strategy

Energies, 2019
On-state voltage is an important thermal parameter for insulated gate bipolar transistor (IGBT) modules. It is employed widely to predict failure in IGBT module bond wires.
Qingyi Kong, Mingxing Du, Ziwei Ouyang, Kexin Wei, William Gerard Hurley   +4 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Water Quality Characteristics and Seasonal Changes in Wastewater Treatment in the Southern Hebei Region by Branch

Toxics
This study analyzed three years of data (2021–2024) from three wastewater treatment plants (WWTPs), namely D, X, and T, in the main urban area of Handan, a typical city in the southern Hebei region, and investigated the influent characteristics and ...
Chao Qu, Weiyuan Cao, Kun Dong, Dunqiu Wang, Yi Yao   +4 more
doaj   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

The Occurrence Characteristics and Ecological Risks of Antibiotics in Surface Water and Groundwater of the Huixian Wetland

Toxics
The concentrations of 17 antibiotics in the surface water and groundwater of a typical river in the Huixian Wetland were measured, and the ecological and health risks of these antibiotics to surface water and groundwater were assessed. The three types of
Dunqiu Wang, Min Li, Chenchen Liao, Kun Dong, Yi Yao   +4 more
doaj   +1 more source

DC Side Bus Voltage Control of Wind Power Grid-Connected Inverter Based on Second-Order Linear Active Disturbance Rejection Control

Energies, 2019
In order to improve the dynamic response speed and the steady-state performance of the DC side bus voltage of the wind power grid-connected inverter, a mathematical model of a typical three-phase voltage type PWM (Pulse Width Modulation, PWM) grid ...
Youjie Ma, Faqing Zhao, Xuesong Zhou, Mao Liu, Bao Yang   +4 more
doaj   +1 more source