Results 111 to 120 of about 5,902,779 (250)

Inferring intrinsic neural timescales using optimal control theory. [PDF]

Nat Commun
Kim JZ, Betzel RF, Beyh A, Howell A, Kuceyeski A, Larsen B, Seguin C, Zhang XH, Holmes A, Parkes L.   +9 more
europepmc   +1 more source

Analysis of fractional order model on higher institution students' anxiety towards mathematics with optimal control theory. [PDF]

Sci Rep, 2023
Teklu SW.
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

CTAS: a network control theory-based approach to identify key regulatory TFs of AS events during epithelial-mesenchymal transition. [PDF]

Brief Bioinform
Gan Y, He Y, Zhao P, Ching WK, Qiu Y.
europepmc   +1 more source

Identifying preeclampsia-associated genes using a control theory method. [PDF]

Brief Funct Genomics, 2022
Li X, Liu L, Whitehead C, Li J, Thierry B, Le TD, Winter M.   +6 more
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Application of key link nursing based on feedforward control theory in the emergency rescue of multiple trauma patients. [PDF]

Front Public Health
Huang Y, Yin F, Ni Y, Zhang Y, Dai C.
europepmc   +1 more source

Investigating Machine Learning and Control Theory Approaches for Process Fault Detection: A Comparative Study of KPCA and the Observer-Based Method. [PDF]

Sensors (Basel), 2023
Lajmi F, Mhamdi L, Abdelbaki W, Dhouibi H, Younes K.   +4 more
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

HIV/AIDS compartmental model analysis with drug resistance treatment, vertical transmission, and optimal control theory. [PDF]

Sci Rep
Peter OJ, Teklu SW, Balogun GB, Bolarin G, Asfaw MD.   +4 more
europepmc   +1 more source