Results 41 to 50 of about 5,902,779 (250)
Linear Control Theory with an ℋ∞ Optimality Criterion [PDF]
, 1987 This expository paper sets out the principal results in ℋ∞ control theory in the context of continuous-time linear systems.
Doyle, John C., Francis, Bruce A.
core +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Optimal control theory with arbitrary superpositions of waveforms
, 2014 Standard optimal control methods perform optimization in the time domain. However, many experimental settings demand the expression of the control signal as a superposition of given waveforms, a case that cannot easily be accommodated using time-local ...
Ankerhold, Joachim +3 more
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Neurocomputational theories of homeostatic control
Physics of Life Reviews, 2019 Homeostasis is a problem for all living agents. It entails predictively regulating internal states within the bounds compatible with survival in order to maximise fitness. This can be achieved physiologically, through complex hierarchies of autonomic regulation, but it must also be achieved via behavioural control.
Oliver J Hulme +2 more
openaire +4 more sources
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
A Linear Control Theory Analysis of Transverse Coherent Bunch Instabilities Feedback Systems (The Control Theory Approach to Hill's Equation) [PDF]
, 1993 There is an on-going effort to build a feedback system for transverse coherent bunch instabilities for ALS [1,2,3]. The beam dynamics issues were already addressed in the conceptual design report [ 4] and more detailed studies have been earned out [5 ...
Bengtsson, Johan +2 more
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Well-posedness and Stability for Interconnection Structures of Port-Hamiltonian Type
, 2019 We consider networks of infinite-dimensional port-Hamiltonian systems $\mathfrak{S}_i$ on one-dimensional spatial domains. These subsystems of port-Hamiltonian type are interconnected via boundary control and observation and are allowed to be of distinct
Augner, Björn
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FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source