Results 191 to 200 of about 426,776 (261)

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Passing the Torch: Reflections on Aging Cell and Translational Geroscience. [PDF]

Aging Cell
Montano M.
europepmc   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Experimental Comparison and Empirical Path Loss Modeling of LoRa Communication in Line-of-Sight and Forest Environments at 923 MHz. [PDF]

Sensors (Basel)
Boonlom K, Khonrang J, Akkaraekthalin P, Chudpooti N.   +3 more
europepmc   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

NURSE-AI: A Nurse-by-Design Framework for Multi-Sensor, AI-Enabled Chronic Wound Assessment in Community Healthcare. [PDF]

Sensors (Basel)
Barchielli C, Jayousi S, Mari R, Albanesi B, Alaimo M, Galeotti G, Zoppi P, Mucchi L.   +7 more
europepmc   +1 more source

Mandatory lane-changing decision and control method based on game theory. [PDF]

PLoS One
Wang Z, Zhang X, Ren H, Yang L.
europepmc   +1 more source

The influence of academic values on academic engagement among Chinese college students: A serial mediation model. [PDF]

PLoS One
Dong J, Yang T, Wei Z, Gu X, Ru Y, Hu L.
europepmc   +1 more source

Development and validation of the TexCoMP model: A nonlinear framework for optimising slip-resistant walkway coatings in diverse environments. [PDF]

PLoS One
Kim IJ.
europepmc   +1 more source