Results 151 to 160 of about 6,093,804 (271)

Towards a Compositional Framework for Describing Human Phenotypes

open access: yesAdvanced Science, EarlyView.
The Phenotype Assembly Method (PhenoAM) decomposes phenotype variables into measurable Features and typed Qualifiers, enabling standardized, machine‐readable Phenome Data Elements (PhenoDEs) that preserve measurement context. Applied in the International Human Phenome Project (IHPP), the framework yields 58 371 PhenoDEs and supports component‐level ...
Wanting Hu   +11 more
wiley   +1 more source

The prognostic impact of the controlling nutritional status (CONUT) score in patients undergoing cardiovascular surgery

open access: yes
主査 : 船橋公彦 / タイトル : The prognostic impact of the controlling nutritional status (CONUT) score in patients undergoing cardiovascular surgery /著者 : Masanori Hara, Takeshiro Fujii, Hiroshi Masuhara, Muneyasu Kawasaki, Keiichi Tokuhiro, Yoshinori Watanabe ...
ハラ, マサノリ   +2 more
core  

Adhesion‐Enhanced Engineered Probiotic for Prolonged Intestinal Retention and Calprotectin‐Responsive IBD Therapy

open access: yesAdvanced Science, EarlyView.
An intelligent engineered probiotic platform is developed for the precision management of inflammatory bowel disease. By integrating surface‐displayed adhesins with an inflammation‐responsive CAT‐SOD‐GPx tripartite fusion system and mucosal repair factors, this programmable system achieves prolonged intestinal retention and multi‐pronged therapy.
Yuxi Wang   +9 more
wiley   +1 more source

RBM25 Drives Hepatocellular Carcinoma Progression by Stabilizing YAP Through Regulating Oncogenic Splicing‐switch of MYPT1

open access: yesAdvanced Science, EarlyView.
This study establishes that the RBM25‐PRPF40A interaction modulates MYPT1 splicing, promoting the production of the oncogenic long isoform. This isoform stabilizes YAP by suppressing its phosphorylation and subsequent proteasomal degradation, ultimately accelerating tumor growth.
Wenjing Zhang   +14 more
wiley   +1 more source

SAT1‐Induced Spermidine Depletion Potentiates Food Allergy

open access: yesAdvanced Science, EarlyView.
Spermidine depletion, driven by upregulated spermidine/spermine N1‐acetyltransferase (SAT1), potentiates food allergy by promoting mast cell degranulation through autophagy suppression. SAT1 physically interacts with the long noncoding RNA Cdk19os to inhibit Atg5 and Atg7, disrupting autophagic flux.
Manman Liu   +8 more
wiley   +1 more source

Controlling Nutritional (Conut) Score for Nutritional Screening in Kidney Transplant Recipients

open access: yes
Purpose: Nutrition is severely impaired in individuals with renal impairment, and transplant often ameliorates this condition. In this study, we aimed to evaluate the controlling nutritional status (CONUT) score of kidney transplant (KT) recipients ...
Demir, S.   +3 more
core   +1 more source

Polarization Holographic 4D Phenotyping Reveals Nanoplastic Induced Dysfunction in Zooplankton

open access: yesAdvanced Science, EarlyView.
Contaminant‐induced dysfunction in complex aquatic organisms remains difficult to resolve across scales. Polarization Holographic Imaging Microscopy (PHIM) integrates polarization‐sensitive holography with computational volumetric reconstruction for label‐free phenotyping of zooplankton in natural seawater, revealing that nanoplastic stress drives ...
Yuxing Li   +8 more
wiley   +1 more source

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