Results 91 to 100 of about 543,535 (285)
Ethics, 2017 Some acts (mala in se) are wrong prior to any social prohibition (e.g., murder). Other acts (mala prohibita) are wrong only once socially prohibited (e.g., traffic violations). This article considers certain obligations of care that parents owe to their children and children to their parents.
openaire +2 more sources
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Revue de la Régulation, 2015 This thesis explores the analytical scope offered by the notion of performativity of economics. After having emphasize that its principal limit was its difficulty of provide a clear theorization of potential failures of performativity, we set a new ...
Nicolas Brisset
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Revue de la Régulation, 2015 Health care financing in Europe has become more private because of the retrenchment of public health insurance, the increased reliance on private insurance, greater cost-sharing and household out-of-pocket payments.
Philippe Batifoulier
doaj +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
JourneyTabanan Regency has 133 villages, 28 of which have become tourist villages in 2023. Several tourist villages hold promotional events through social media. Generation Z uses social media the most, but tourist village managers have not involved Generation
Anak Agung Ketut Sri Candrawati +2 more
doaj +1 more source
Développement Durable et Territoires, 2017 Public authorities in charge of preparing and implementing the 1964 French water law and the 2000 European Water framework Directive similarly relied on inventories. In order to justify public action, they needed to objectify a situation which was either
Gabrielle Bouleau +3 more
doaj +1 more source