Results 101 to 110 of about 442,501 (289)
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
United States Pharmacopeial Convention (USP)
Регуляторные исследования и экспертиза лекарственных средств, 2018 The United States Pharmacopeial Convention (USP) is a non-profit, non-governmental public health organization that creates documentary and material reference standards for prescription and over-the-counter medicines that are recognized in United States ...
Ronald T. Piervincenzi
doaj
THE RED ARMY AND THE CHANGING OF THE POLITICAL SYSTEM IN ROMANIA [PDF]
Annals: Series on History and Archaeology (Academy of Romanian Scientists), 2013 The radical transformation of Romanian society and its transition to a system similar to that in the Soviet Union implied, on the one hand, the elimination of the influence exerted by the traditional (historical) parties, and, on the other hand,
Constantin HLIHOR, Ioan SCURTU
doaj
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
ПравоприменениеThe subject. The number of authors who consistently try in their works to “bury” international justice, as well as international law itself, behind the ideas of politicization, bias and unenforceability, has grown significantly today.
O. A. Kiseleva
doaj +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Conventional Necessity and the Contingency of Convention
Dialectica, 1987 I defend a conventionalist view of logical and (some) mathematical truths against the criticisms of Quine and Stroud. Conventionalism is best formulated by appealing to sense-conferring rules governing important logical and mathematical expressions. Conventional necessity can be understood as arising from these rules in a way that is immune to Quine's ...
openaire +1 more source
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard +5 more
wiley +1 more source