Convention on the rights of the child

Results 71 to 80 of about 12,574 (254)

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley +1 more source

From International Mandate to National Legislation: Pakistan’s Response to Erga Omnes Obligations on Child Sexual Abuse

Journal of Legal Studies
This article critically assesses Pakistan’s compliance with erga omnes obligations under the Convention on the Rights of the Child (CRC) concerning sexual abuse of children.
Ali Muhammad Imran
doaj +1 more source

Global norms, organizational action: Leveraging international children’s rights law to advance child safeguarding

Leiden Journal of International Law
Tragically, the abuse of children within organizational contexts continues to persist across time and geographies. Various institutions established for children’s care and protection have repeatedly been exposed as epicentres of abuse.
Afrooz Kaviani Johnson
doaj +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source

Elevated Connectivity During Language Processing Is Associated With Cognitive Performance in SeLECTS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Self‐Limited Epilepsy with Centrotemporal Spikes (SeLECTS) is associated with language impairments despite seizures originating in the motor cortex, suggesting aberrant cross‐network interactions. Here we tested whether functional connectivity in SeLECTS during language tasks predicts language performance.
Wendy Qi +8 more
wiley +1 more source

Children’s rights and needs during war: the case of adolescents in Israel

Frontiers in Psychology
IntroductionThis study aims to examine the attainment of rights and needs of adolescents during the war following the October 7th 2023 terror attack on Israel.
Yonat Rum +3 more
doaj +1 more source

Comparative Study of the Right to Education of Children from the perspective of the Convention on the Rights of the Child and the Constitutional Law of Iran [PDF]

حقوق عمومی تطبیقی
The right to education is one of the basic and fundamental rights that is considered among the basic human rights. This right has been emphasized at the global level under conventions, international covenants, the Universal Declaration of Human Rights ...
Milad Kashi Komijani, mahdi rajaei
doaj +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu +21 more
wiley +1 more source

Challenges in Implementing Sharia-Based Education: Balancing Regional Autonomy and Children’s Rights in Aceh

Khazanah Hukum
This study analyzes the implementation of Sharia-based education in Aceh through the perspective of regional autonomy and children's rights. This multidisciplinary study reveals the tension between Aceh's education policies (Law No.
Mukhlis Mukhlis +3 more
doaj +1 more source

Predictive Ability of Plasma p‐tau217 for β‐Amyloid Status: A Prospective Multicenter Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Plasma tau phosphorylated at threonine 217 (p‐tau217) measured with fully automated platforms has shown high accuracy for Alzheimer's disease (AD) diagnosis, but real‐world multicenter data remain limited. We aimed to validate the diagnostic performance of p‐tau217 for identifying AD pathology in a real‐world multicenter cohort ...
Miquel Massons +33 more
wiley +1 more source

16. peace & justice
child
children’s rights

child rights
the convention on the rights of the child
human rights

best interests of the child
10. no inequality
children's rights