Results 71 to 80 of about 11,308 (253)

Global norms, organizational action: Leveraging international children’s rights law to advance child safeguarding

open access: yesLeiden Journal of International Law
Tragically, the abuse of children within organizational contexts continues to persist across time and geographies. Various institutions established for children’s care and protection have repeatedly been exposed as epicentres of abuse.
Afrooz Kaviani Johnson
doaj   +1 more source

Comparative Study of the Right to Education of Children from the perspective of the Convention on the Rights of the Child and the Constitutional Law of Iran [PDF]

open access: yesحقوق عمومی تطبیقی
The right to education is one of the basic and fundamental rights that is considered among the basic human rights. This right has been emphasized at the global level under conventions, international covenants, the Universal Declaration of Human Rights ...
Milad Kashi Komijani, mahdi rajaei
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

open access: yesMolecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Children’s rights and needs during war: the case of adolescents in Israel

open access: yesFrontiers in Psychology
IntroductionThis study aims to examine the attainment of rights and needs of adolescents during the war following the October 7th 2023 terror attack on Israel.
Yonat Rum   +3 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

open access: yesMolecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla   +4 more
wiley   +1 more source

Challenges in Implementing Sharia-Based Education: Balancing Regional Autonomy and Children’s Rights in Aceh

open access: yesKhazanah Hukum
This study analyzes the implementation of Sharia-based education in Aceh through the perspective of regional autonomy and children's rights.  This multidisciplinary study reveals the tension between Aceh's education policies (Law No.
Mukhlis Mukhlis   +3 more
doaj   +1 more source

RATIFIKASI KONVENSI TENTANG HAK-HAK ANAK DALAM SISTEM PERATURAN PERUNDANG-UNDANGAN DI INDONESIA

open access: yesYuridika, 2017
The Convention on the Rights of the Child (CRC) is the most comprehensive human rights treaty and legal instrument for the promotion and protection of children’s rights.
Zendy Wulan Ayu Widhi Prameswari
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

open access: yesMolecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche   +10 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

open access: yesFEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong   +3 more
wiley   +1 more source

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