Results 91 to 100 of about 43,716 (291)

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Digital Denture Cast-Free Workflow Merging Concepts and Advantages of Mucostatics and Mucocompressive Philosophies

Oral
Background: Mucostatic impressions have been always indicated in thin, sharp, or flabby ridges, and have been addressed for their beneficial effect on long-term residual ridge stability.
Lucio Lo Russo, Laura Guida, Mauro Lorusso, Alfredo De Lillo, Domenico Ciavarella, Fariba Esperouz   +5 more
doaj   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Comparison of the suitability of intra-oral scanning with conventional impression of edentulous maxilla in vivo. A preliminary study [PDF]

, 2018
Aim According to recent literature, the accuracy of digital impression can be compared with traditional impressions for most indications. However, little is known about their suitability in digitizing edentulous jaws in view of mobile prosthetic ...
D'Arienzo L. F., D'Arienzo A., Borracchini A.   +2 more
core   +1 more source

A Randomized Controlled Trial to Evaluate and Compare the Vertical Marginal Fit of Monolithic Zirconia Crowns Obtained Using Intraoral Scanning vs Monophase Impression Technique: An In Vivo Study

Journal of Pharmacy and Bioallied Sciences
Background: The marginal fit of dental restorations is a critical factor influencing their longevity and clinical success. With the advent of digital dentistry, intraoral scanning has emerged as an alternative to conventional impression techniques ...
Rushikesh Narsing Kaknale, Rajiv Kumar Gupta, Akshay Bhargava, Bharti Dua, Manoj Kumar Goyat, Mahitosh Ashokrao Lakhe   +5 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Evaluation of the Internal Accuracy of Molar Crowns Fabricated Using Digital and Conventional Impression Techniques

, 2018
Objective: The purpose of this in vitro study was to compare the internal gaps of 3 different full molar crowns prepared using digital and conventional impression techniques.
Emrah Ayna, Tartuk, Bulent Kadir, Emine Göncü Başaran, Ayna, Emrah, Bülent Kadir Tartuk, Basaran, Emine Goncu   +5 more
core   +1 more source

Conventional and Digital Impression Techniques in Implant Prosthetics

, 2022
Protetik diş tedavisinde ölçü işlemi, diş ya da implantların ve ağız için dokuların negatif formunun elde edilerek alçı ya da farklı materyaller ile çalışma modellerinin elde edilmesindeki ilk aşamadır.
Melek Sultan KİRAZ, Kiraz, Melek Sultan, ÇEVİK, PINAR, Pınar ÇEVİK, Çevik, Pınar   +4 more
core   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source