Results 111 to 120 of about 2,065,084 (286)

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Corporate governance and impression management in annual press releases [PDF]

We study the association between corporate governance and impression management in annual results press releases (ARPRs). Press releases constitute a timely vehicle to communicate firm performance to third parties.
Beatriz García Osma, Encarna Guillamón Saorín   +1 more
core  

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Evaluation of the Accuracy of Conventional and Digital Impression Techniques for Implant Restorations

, 2018
PURPOSE The increased use of CAD systems can generate doubt about the accuracy of digital impressions for angulated implants. The aim of this study was to evaluate the accuracy of different impression techniques, two conventional and one digital, for ...
Alfredo Mikail Melo Mesquita, Özcan, Mutlu, Ivan Balducci, Moura, Renata Vasconcellos, Bassolli, Lucas, Mesquita, Alfredo Mikail Melo, Mutlu Özcan, Cintia Helena Coury Saraceni, Alberto Noriyuki Kojima, Renata Vasconcellos Moura, Balducci, Ivan, Kojima, Alberto Noriyuki, Saraceni, Cintia Helena Coury, Lucas Bassolli   +13 more
core   +1 more source

Comparisons in satisfaction of dental patients who experienced both conventional impression and digital impression

, 2016
최근 디지털 기술이 치과 임상 및 기공 과정에 응용되면서 인상채득 과정에서 인상재를 사용하지 않고, 구강 내를 직접 스캔하여 디지털 데이터로 전환한 후 컴퓨터를 기반으로 보철물을 디자인, 제작하는 디지털 작업 방식이 널리 사용되고 있다. 본 연구에서는 전통적 인상채득과 디지털 인상채득을 모두 경험한 환자들의 주관적인 만족도를 조사해 봄으로써 디지털 인상채득의 임상적 활용 현황 파악 및 향후 고려사항에 대하여 알아보고자 하였다.
이수민
core   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

The accuracy of stereophotogrammetric, intraoral scanning, and conventional open-tray impression techniques for complete arch fixed implant-supported prostheses: An in vitro study

Digital Dentistry Journal
Objectives: This study compares the accuracy (trueness and precision) of stereophotogrammetric (SPG), intraoral scanning (IOS), and conventional (CI) techniques for complete-arch fixed implant-supported prostheses with three different distal implant ...
Sasithorn Lohatchwanit, Walita Narkbuakaew, Weerapan Aunmeungtong, Pathawee Khongkhunthian   +3 more
doaj   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source