Results 41 to 50 of about 668 (250)

The non-application of the constitutional purpose of danger to the community in the insurance measure in light of the Inter-American System

Postulados: Revista Sociojurídica
Diffuse control has been established as a tool that allows the member states of the American Convention on Human Rights to specify in all areas, especially in the jurisdictional area, the obligations to respect and guarantee human rights, through the ...
Fernanda Liliana Coca Medina, Yenny Yazmin Ortiz Barrera   +1 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

El principio de legalidad y el control de convencionalidad de las leyes: confluencias y perspectivas en el pensamiento de la Corte Interamericana de Derechos Humanos

Boletín Mexicano de Derecho Comparado, 2010
Número 128 Mayo - Agosto 2010ISSN 0041 8633 EL PRINCIPIO DE LEGALIDAD Y EL CONTROL DE CONVENCIONALIDAD DE LAS LEYES: CONFLUENCIAS Y PERSPECTIVAS EN EL PENSAMIENTO DE LA CORTE INTERAMERICANA DE DERECHOS HUMANOS* THE LEGALITY PRINCIPLE AND THE ...
María Carmelina Londoño Lázaro
doaj   +1 more source

Conventionality Control (American Convention on Human Rights) [PDF]

SSRN Electronic Journal, 2014
This article proposes to analyse the ways of conventionality control under Brazilian law as well the conventionality control by the Inter-American Court of Human Rights. Besides, the article analyses the object and parameter for conventionality control in the Inter-American Court and the power of his precedents over national courts.
openaire   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

CONTROL OF CONVENTIONALITY

, 2017
A pesar de la diversidad de intereses de los Estados, la idea de la constitución de las reglas de conducta de la sociedad internacional, cuanto a la protección de los derechos humanos es cada vez más premente. Así, los conceptos y recomendaciones tradicionalmente consagrados por el derecho internacional, por ejemplo la soberania de los Estados, los ...
openaire   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

La internacionalización de la Carta Magna española de 1978: signo de madurez constitucional // Internationalization of the 1978 Spanish Magna Carta: A Sign of Constitutional Maturity

Revista de Derecho Político, 2018
Resumen: La presente contribución adopta como hipótesis de partida la relativa influencia de los estándares internacionales en la redacción de la Constitución de 1978 y la absoluta necesidad de adaptación a la realidad del Estado supranacional e ...
Luis Jimena Quesada
doaj   +1 more source