Results 91 to 100 of about 6,286 (288)
Desenvolvimento e Meio Ambiente, 2017 The fast development of markets for organic products has led to a process called conventionalization of organic agriculture. This process has been directly influencing the maintenance of agroecological principles, as well as access to these markets by ...
Maurício da Trindade Viegas +2 more
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The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Targeting p38α in cancer: challenges, opportunities, and emerging strategies
Molecular Oncology, EarlyView.p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley +1 more source
Multimodal Existential Negation in Ecuadorian Highland Kichwa
LanguagesConventionalized or symbolic “emblematic” visual expressions are the types of “gesture” that most closely resemble lexical and grammatical elements seen in spoken languages or in sign languages in the visual modality.
Simeon Floyd
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The taste for the particular: A logic of discernment in an age of omnivorousness [PDF]
, 2016 This article provides an analysis of two leading specialist wine magazines, Decanter and Wine Spectator, and the codification and legitimation of a ‘taste for the particular.’ Such media of connoisseurship are key institutions of evaluation and ...
Bourdieu P +15 more
core +2 more sources
Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity
Molecular Oncology, EarlyView.Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek +2 more
wiley +1 more source
Note sur l’adverbe temporel już et ses correspondants français
Cognitive Studies | Études cognitives, 2015 A remark concerning the temporal adverb już and its French equivalents Generally speaking, this contrastive study of the Polish temporal adverb już and the French déjà is based around the idea that już and déjà have an invariant meaning but it is also ...
Małgorzata Nowakowska, Denis Apothéloz
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Argumentative patterns in discourse [PDF]
, 2013 This paper discusses the ways in which argumentative discourse prototypically manifests itself. As a consequence of the institutional preconditions applying to the strategic manoeuvring taking place in specific communicative activity types, certain ...
Garssen, Bart, van Eemeren, Frans H.
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Molecular Oncology, EarlyView.To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley +1 more source
Cognitive LinguisticsThis paper scrutinizes the conventionalization of the Spanish expression la de que (‘the amount of that’), a reduced variant of la cantidad de que. The study seeks to determine the diachrony of and mechanisms underlying the emergence and diffusion of ...
Marttinen Larsson Matti
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