Results 81 to 90 of about 6,286 (288)

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

The Interlocutor in Print and Digital Fiction: Dialogicity, Agency, (De-)Conventionalization

MatLit, 2018
Digital fiction typically puts the reader/player in a cybernetic dialogue with various narrative functions, such as characters, narrative voices, or prompts emanating from the storytelling environment.
Astrid Ensslin
doaj   +1 more source

A Bi-Polar Theory of Nominal and Clause Structure and Function [PDF]

, 2004
It is taken as axiomatic that grammar encodes meaning. Two key dimensions of meaning that get grammatically encoded are referential meaning and relational meaning.
Ball, Dr. Jerry T.
core  

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Assessing the Rise of Organic Farming in the European Union: Environmental and Socio-economic Consequences [PDF]

Although organic farming is considered the poster child of rural development in Europe, there is little empirical evidence assessing its success in achieving the ambitious environmental and socio-economic objectives that it is purported to assist.
Charalampos Konstantinidis
core  

Neural correlates of the processing of co-speech gestures [PDF]

, 2007
In communicative situations, speech is often accompanied by gestures. For example, speakers tend to illustrate certain contents of speech by means of iconic gestures which are hand movements that bear a formal relationship to the contents of speech.
Alibali, Allison, Andreas Hennenlotter, Baddeley, Beattie, Beattie, Beauchamp, Beauchamp, Beauchamp, Binkofski, Calvert, Calvert, Cassell, Chomsky, Culham, Dupont, Feyereisen, Fiebach, Fiez, Fridman, Friston, Gallese, Gallese, Gauthier, Gauthier, Goldin-Meadow, Grill-Spector, Grodzinsky, Grosjean, Gunter, Gunter, Hadar, Henning Holle, Holle, Holler, Iacoboni, Iacoboni, Iacoboni, Josephs, Joubert, Kanwisher, Kelly, Kita, Krauss, Lee, Levelt, Lohmann, Marco Iacoboni, McNeill, McNeill, Molnar-Szakacs, Morrel-Samuels, Nixon, Nobe, Norris, Oldfield, Paulesu, Pelphrey, Rizzolatti, Rizzolatti, Rizzolatti, Rose, Saygin, Schubotz, Sekiyama, Shirley-Ann Rüschemeyer, Skipper, Tanenhaus, Tarr, Thomas C. Gunter, Ugurbil, Umiltà, van Atteveldt, Ward, Worsley, Wright, Wu, Özyürek   +77 more
core   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Introduction: Exploring feminist ecological economics [PDF]

, 2005
These Explorations argue that more links between the fields of feminist ecology and feminist economics are both needed and promising, and presents new, boundary-crossing research in this area.
Kuiper, E., Perkins, Patricia E. (Ellie)
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Conventionalization, expectation, politeness and pragmatic impact: A German perspective

Linguistik Online
While politeness has originally been closely associated with indirectness in early politeness research, the field has since moved to a view that conventionalized indirectness tends to be the preferred option by interlocutors.
Stefanie Stadler
doaj   +1 more source