Results 41 to 50 of about 35,487 (280)

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Effectiveness of vision therapy in school children with symptomatic convergence insufficiency

Journal of Ophthalmic & Vision Research, 2017
Purpose: To determine the effectiveness of vision therapy among Korean elementary school children with convergence insufficiency. Methods: A total of 235 elementary schoolchildren, 10.13 ± 2.45 years of age, were subjected to thorough eye examination ...
Jung Un Jang, Jung Yun Jang, Kim Tai-hyung, Hwang Woon Moon   +3 more
doaj   +1 more source

Development of a novel clinical scoring system for on-farm diagnosis of bovine respiratory disease in pre-weaned dairy calves. [PDF]

, 2014
Several clinical scoring systems for diagnosis of bovine respiratory disease (BRD) in calves have been proposed. However, such systems were based on subjective judgment, rather than statistical methods, to weight scores.
Aly, Sharif S, Kass, Philip H, Lehenbauer, Terry W, Love, William J, Van Eenennaam, Alison L   +4 more
core   +2 more sources

Enhancing Oncological Care for India's Aging Population: Addressing the Complex Needs of Older Adults With Cancer

Aging and Cancer, EarlyView.
Aging‐associated physiological and molecular alterations pose significant challenges in cancer management among India's elderly. Limited geriatric oncology expertise, financial constraints, and inadequate specialized care exacerbate disparities. Strategic expansion of insurance coverage, integration of palliative care, and infrastructural advancements ...
Nihanthy D. Sreenath, Mathigatta Shivarudraiah S, Rajath Govind, Kaushik M R   +3 more
wiley   +1 more source

Predicting and Comparing the Subjective Health Experience of Older Cancer Survivors and Non‐Cancer Survivors: A Modeling Approach

Aging and Cancer, EarlyView.
This study underscores the significant influence of frailty and vitality on the subjective health experience of older cancer survivors with acceptance and control emerging as salient mediators. These findings affirm the conceptual and empirical robustness of the model highlighting its potential utility in shaping future interventions for older cancer ...
Damien S. E. Broekharst, Sjaak Bloem, Eline J. Mertens, Nathascha Hanzen, Michel van Agthoven   +4 more
wiley   +1 more source

Visual problems among video display terminal (VDT) users in Nepal

Journal of Optometry, 2011
Purpose: To evaluate visual problems, major symptoms, and their associations among VDT users in Nepal. Methods: Among 76 hospital attendees, assessment included visual acuity, retinoscopy, convergence, accommodation, fusional vergence and Schirmer's II ...
Gauri Shankar Shrestha, Fathimath Nestha Mohamed, Dev Narayan Shah   +2 more
doaj   +1 more source

Comparing myopic error in patients with basic and convergence insufficiency intermittent exotropia in China

BMC Ophthalmology, 2023
Purpose To compare the degree of myopia between the dominant and non-dominant eyes in teenagers with intermittent exotropia (IXT) in China. Methods A total of 199 IXT patients with myopia were included in this retrospective study and were divided into ...
Qingyu Meng, Lejin Wang, Mingwei Zhao, Xi Wu, Lili Guo   +4 more
doaj   +1 more source

Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon, Nathalie Picard, Valeria d'Andrea, Enchi Chang, Joseph Leffler, Eleonora Centofante, Matthew Taylor, Francesca Bardi, Francesca Cavicchiolo, Takao K. Hensch, Stefano Panzeri, Chinfei Chen, Michela Fagiolini   +12 more
wiley   +1 more source

Clinical association between teeth malocclusions, wrong posture and ocular convergence disorders: an epidemiological investigation on primary school children

BMC Pediatrics, 2013
Background As the various systems in the body are inter-connected to form a single structural unit, a pathological condition in one area can also affect other areas. There are many known correlations between the visual and motor system. The importance of
Silvestrini-Biavati Armando, Migliorati Marco, Demarziani Eleonora, Tecco Simona, Silvestrini-Biavati Piero, Polimeni Antonella, Saccucci Matteo   +6 more
doaj   +1 more source