Results 41 to 50 of about 861,931 (295)

Ocular dirofilariasis: a clinicopathologic case series and literature review

, 2023
Purpose Ocular dirofilariasis is an uncommon zoonotic infection that is usually associated with a carnivore host. In this case series and literature review we investigate the clinical presentation, management, and histopathology of ocular dirofilariasis.
Clauss, Kevin D., Kunkler, Anne L., Antonietti, Michael, Lee, Wendy W., Yoo, Sonia H., Muniz-Castro, Hannah, Camacho, Matthew, Sayegh, Yoseph, Johnson, Thomas E., Dubovy, Sander R., Colson, Jordan D.   +10 more
core   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

The role of inflammation and fibroblasts in conjunctival scarring in ocular mucous membrane pemphigoid [PDF]

, 2009
Ocular mucous membrane pemphigoid (ocular MMP) is a visually devastating disease where up to 30% of patients become blind due to the consequences of conjunctival inflammation and aggressive fibrosis.
Saw, V.P.J.
core  

Estimating household and community transmission of ocular Chlamydia trachomatis. [PDF]

, 2009
INTRODUCTION: Community-wide administration of antibiotics is one arm of a four-pronged strategy in the global initiative to eliminate blindness due to trachoma. The potential impact of more efficient, targeted treatment of infected households depends on
Anthony W Solomon, Muñoz Beatriz, Solomon, AW, Martin J Holland, Manoj Gambhir, Sheila West, Gambhir Manoj, Bailey Robin L., West, S, Basáñez María-Gloria, María-Gloria Basáñez, Bailey, RL, David C W Mabey, Basanez, M-G, Basáñez, María-Gloria, Grassly, NC, Nicholas C Grassly, Munoz, B, Mabey, DCW, Solomon, Anthony W, Gambhir, Manoj, Blake Isobel M., Blake, Isobel M, Solomon Anthony W., Burton, Matthew J, Burton Matthew J., Mabey David C. W., Grassly, Nicholas C, Beatriz Muñoz, Muñoz, Beatriz, Robin L Bailey, Holland, MJ, Bailey, Robin L, West, Sheila, Holland, Martin J, Blake, IM, Gambhir, M, West Sheila, Grassly Nicholas C., Isobel M Blake, Matthew J Burton, Holland Martin J., Mabey, David CW, Burton, MJ   +43 more
core   +2 more sources

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Validated prediction model for the development of primary open-angle glaucoma in individuals with ocular hypertension

, 2007
Objective To test the validity and generalizability of the Ocular Hypertension Treatment Study (OHTS) prediction model for the development of primary open-angle glaucoma (POAG) in a large independent sample of untreated ocular hypertensive individuals
N. Orzalesi, Ocular Hypertension Treatment Study Group, European Glaucoma Prevention Study Group, L.M. Rossetti   +3 more
core   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

Effectiveness of vision therapy in school children with symptomatic convergence insufficiency

Journal of Ophthalmic & Vision Research, 2017
Purpose: To determine the effectiveness of vision therapy among Korean elementary school children with convergence insufficiency. Methods: A total of 235 elementary schoolchildren, 10.13 ± 2.45 years of age, were subjected to thorough eye examination ...
Jung Un Jang, Jung Yun Jang, Kim Tai-hyung, Hwang Woon Moon   +3 more
doaj   +1 more source