Results 131 to 140 of about 1,144,972 (240)

Breakthrough Design of Highly Potent Antivirals Against Wild‐Type HIV‐1 and Lenacapavir‐Resistant M66I Variant

open access: yesAngewandte Chemie, EarlyView.
Lenacapavir, the first‐in‐class drug targeting HIV‐1 capsid, is a breakthrough drug in HIV‐1 treatment and prophylaxis. However, a single M66I mutation confers complete viral resistance to lenacapavir. We report herein the design and synthesis of innovative R2 analogs demonstrating low nM potency against HIV‐1 M66I and excellent pharmacokinetics in ...
Nicolas Jamey   +13 more
wiley   +1 more source

Template‐Encoded Assembly and Adaptive Function in Selenium‐Based Molybdenum Chalcoxide Rings

open access: yesAngewandte Chemie, EarlyView.
External templates write structural information into Se‐containing molybdenum rings, while selenium's softness confers adaptive host–guest behaviour and catalytic responsiveness, an integrated framework for programmable inorganic function. ABSTRACT Controlling both structure and function in inorganic self‐assembly remains a major challenge.
Giulia Pellegrino   +4 more
wiley   +1 more source

Variational Ball Skinning

open access: yes, 2008
. This paper considers the problem of computing an interpolating envelope of an ordered set of 2D balls. By construction, the envelope is constrained to be C 1 continuous, and for each ball, it touches the ball at a point and is tangent to the ball at ...
Greg Slabaugh   +4 more
core  

Radical, Not Ionic: The Mechanochemical Zincke Nitration of Phenols

open access: yesAngewandte Chemie, EarlyView.
Mechanochemistry recasts the classical Zincke nitration as an open‐shell process. Liquid‐assisted vibrational milling of phenols with in situ HNO2 delivers direct and ipso nitration across 50 substrates, while atmosphere, NOx‐transfer, EPR and DFT evidence expose a phenoxyl‐radical/NO2 manifold underlying this historically ionic transformation ...
Roberto Scipione   +7 more
wiley   +1 more source

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