Results 41 to 50 of about 1,208,437 (281)

Direct numerical simulation of hypersonic boundary layer transition over a lifting-body model HyTRV

open access: yesAdvances in Aerodynamics, 2021
Direct numerical simulation (DNS) of transition over a hypersonic lifting body model HyTRV developed by China Aerodynamics Research and Development Center is performed.
Han Qi   +3 more
doaj   +1 more source

Free Stein kernels and an improvement of the free logarithmic Sobolev inequality

open access: yes, 2016
We introduce a free version of the Stein kernel, relative to a semicircular law. We use it to obtain a free counterpart of the HSI inequality of Ledoux, Peccatti and Nourdin, which is an improvement of the free logarithmic Sobolev inequality of Biane and
Fathi, Max, Nelson, Brent
core   +1 more source

Fully Projection-Free Proximal Stochastic Gradient Method With Optimal Convergence Rates

open access: yesIEEE Access, 2020
Proximal stochastic gradient plays an important role in large-scale machine learning and big data analysis. It needs to iteratively update models within a feasible set until convergence.
Yan Li, Xiaofeng Cao, Honghui Chen
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

A global observer for attitude and gyro biases from vector measurements

open access: yes, 2016
We consider the classical problem of estimating the attitude and gyro biases of a rigid body from vector measurements and a triaxial rate gyro. We propose a simple "geometry-free" nonlinear observer with guaranteed uniform global asymptotic convergence ...
Martin, Philippe, Sarras, Ioannis
core   +3 more sources

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

open access: yesFEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López   +2 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

Global regularity and probabilistic schemes for free boundary surfaces of multivariate American derivatives and their Greeks

open access: yes, 2010
In a rather general setting of multivariate stochastic volatility market models we derive global iterative probabilistic schemes for computing the free boundary and its Greeks for a generic class of American derivative models using front-fixing methods ...
Kampen, Joerg
core   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

open access: yesMolecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller   +17 more
wiley   +1 more source

Semilocal Convergence Theorem for the Inverse-Free Jarratt Method under New Hölder Conditions

open access: yesThe Scientific World Journal, 2015
Under the new Hölder conditions, we consider the convergence analysis of the inverse-free Jarratt method in Banach space which is used to solve the nonlinear operator equation. We establish a new semilocal convergence theorem for the inverse-free Jarratt
Yueqing Zhao   +5 more
doaj   +1 more source

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