Results 61 to 70 of about 1,208,437 (281)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Semi-Local Convergence of Two Derivative-Free Methods of Order Six for Solving Equations under the Same Conditions

Foundations, 2022
We propose the semi-local convergence of two derivative-free, competing methods of order six to address non-linear equations. The sufficient convergence criteria are the same, making a direct comparison between them possible.
Ioannis K. Argyros, Christopher I. Argyros, Jinny Ann John, Jayakumar Jayaraman   +3 more
doaj   +1 more source

Local limit theorems in free probability theory

, 2010
In this paper, we study the superconvergence phenomenon in the free central limit theorem for identically distributed, unbounded summands. We prove not only the uniform convergence of the densities to the semicircular density but also their $L^p ...
Wang, Jiun-Chau
core   +1 more source

Convergence of single-step free energy perturbation

Molecular Physics, 2016
The convergence of free energy perturbation (Zwanzig's equation) and its non-equilibrium extension (Jarzynski's equation) is herein investigated from a practical point of view. We focus on cases where neither intermediate steps nor two-sided methods (Bennett, Crooks) can be used to compute the free energy difference of interest.
Boresch, Stefan, Woodcock, H. Lee
openaire   +2 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Double Hyperbolic Reaching Law With Chattering-Free and Fast Convergence

IEEE Access, 2018
This paper proposes a novel continuous reaching law for chattering-free sliding mode control by using two hyperbolic functions with similar changing rate and opposite amplitude characteristics.
Liang Tao, Qiang Chen, Yurong Nan, Chun Wu   +3 more
doaj   +1 more source

Extra-Regional Influence on the Development of Economic Integration in the ASEAN Region

Евразийская интеграция: экономика, право, политика, 2023
This study discusses the extra-regional influence and scenarios for the development of regional integration of the countries of the Association of States Southeast Asia (ASEAN), in particular, the role of the future free trade agreement between the EAEU ...
A. M. Titovich, A. V. Toropygin
doaj   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Convergence of digitized-counterdiabatic QAOA: circuit depth versus free parameters

New Journal of Physics
Recently, digitized-counterdiabatic (CD) quantum approximate optimization algorithm (QAOA) has been proposed to make QAOA converge to the solution of an optimization problem in fewer steps, inspired by Trotterized CD driving in continuous-time quantum ...
Mara Vizzuso, Gianluca Passarelli, Giovanni Cantele, Procolo Lucignano   +3 more
doaj   +1 more source

On highly efficient derivative-free family of numerical methods for solving polynomial equation simultaneously

Advances in Difference Equations, 2021
A highly efficient new three-step derivative-free family of numerical iterative schemes for estimating all roots of polynomial equations is presented.
Mudassir Shams, Naila Rafiq, Nasreen Kausar, Praveen Agarwal, Choonkil Park, Nazir Ahmad Mir   +5 more
doaj   +1 more source